Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Gebhard C, Buechel RR, Stahli BE, Gransar H, Achenbach S, Berman DS, Budoff MJ, Canister TQ, Chow B, Dunning A, Al-Mallah MH, Cademartiri F, Chinnaiyan K, Rubinshtein R, Marques H, Delago A, Villines TC, Hadamitzky M, Hausleiter J, Shaw LJ, Cury RC, Feuchtner G, Kim YJ, Maffei E, Raff G, Pontone G, Andreini D, Chang HJ, Leipsic J, Minn JK, Kaufmann PA (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 18

Pages Range: 990-1000

Journal Issue: 9

DOI: 10.1093/ehjci/jew142

Abstract

Background: Left ventricular (LV) volumetric and functional parameters measured with cardiac computed tomography (cardiac CT) augment risk prediction and discrimination for future mortality. Gender- and age-specific standard values for LV dimensions and systolic function obtained by 64-slice cardiac CT are lacking. Methods and results: 1155 patients from the Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry (54.5% males, mean age 53.1 ± 12.4 years, range: 18-92 years) without known coronary artery disease (CAD), structural heart disease, diabetes, or hypertension who underwent cardiac CT for various indications were categorized according to age and sex. A cardiac CT data acquisition protocol was used that allowed volumetric measuring of LV function. Image interpretation was performed at each site. Patients with significant CAD (>50% stenosis) on cardiac CT were excluded from the analysis. Overall, mean left ventricular ejection fraction (LVEF) was higher in women when compared with men (66.6 ± 7.7% vs. 64.6 ± 8.1%, P < 0.001). This gender-difference in overall LVEF was caused by a significantly higher LVEF in women ≥70 years when compared with men ≥70 years (69.95 ± 8.89% vs. 65.50 ± 9.42%, P = 0.004). Accordingly, a significant increase in LVEF was observed with age (P = 0.005 for males and P < 0.001 for females), which was more pronounced in females (5.21%) than in males (2.6%). LV end-diastolic volume decreased in females from 122.48 ± 27.87 (<40 years) to 95.56 ± 23.17 (>70 years; P < 0.001) and in males from 155.22 ± 35.07 (<40 years) to 130.26 ± 27.18 (>70 years; P < 0.001). Conclusion: Our findings indicate that the LV undergoes a lifelong remodelling and highlight the need for age and gender adjusted reference values.

Authors with CRIS profile

Involved external institutions

Universitätsspital Zürich (USZ) Switzerland (CH) Cedars-Sinai Medical Center United States (USA) (US) Harbor–UCLA Medical Center United States (USA) (US) Tennessee Heart & Vascular United States (USA) (US) University of Ottawa Canada (CA) Duke University Medical Center United States (USA) (US) Wayne State University (WSU) United States (USA) (US) Casa di Cura Giovanni XXIII Italy (IT) Beaumont Health System United States (USA) (US) Technion - Israel Institute of Technology Israel (IL) Hospital Curry Cabral Portugal (PT) Capitol Cardiology Associates United States (USA) (US) Walter Reed Army Medical Center (WRAMC) United States (USA) (US) Emory University United States (USA) (US) Università degli studi di Milano Italy (IT) University of British Columbia Canada (CA) New York Presbyterian Hospital United States (USA) (US) Deutsches Herzzentrum München Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Baptist Health South Florida United States (USA) (US) Medizinische Universität Innsbruck Austria (AT) Seoul National University (SNU) / 서울대학교 Korea, Republic of (KR) Yonsei University Korea, Republic of (KR)

How to cite

APA:

Gebhard, C., Buechel, R.R., Stahli, B.E., Gransar, H., Achenbach, S., Berman, D.S.,... Kaufmann, P.A. (2017). Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study. European Heart Journal - Cardiovascular Imaging, 18(9), 990-1000. https://doi.org/10.1093/ehjci/jew142

MLA:

Gebhard, Catherine, et al. "Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study." European Heart Journal - Cardiovascular Imaging 18.9 (2017): 990-1000.

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