FFR Derived From Coronary CT Angiography in Nonculprit Lesions of Patients With Recent STEMI

Journal article

Publication Details

Author(s): Gaur S, Taylor CA, Jensen JM, Botker HE, Christiansen EH, Kaltoft AK, Holm NR, Leipsic J, Zarins CK, Achenbach S, Khem S, Wilk A, Bezerra HG, Lassen JF, Norgaard BL
Journal: Journal of the American College of Cardiology : Cardiovascular imaging
Publication year: 2017
Volume: 10
Journal issue: 4
Pages range: 424-433
ISSN: 1936-878X
eISSN: 1876-7591


OBJECTIVES: This study sought to determine the diagnostic performance of noninvasive fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) (FFRCT) for the diagnosis of lesion-specific ischemia in nonculprit vessels of patients with recent in ST-segment elevation myocardial infarction (STEMI).
BACKGROUND: In patients with stable angina, FFRCThas high diagnostic performance in identification of ischemia-causing lesions. The potential value of FFRCTfor assessment of multivessel disease in patients with recent STEMI has not been evaluated.
METHODS: Coronary CTA with calculation of FFRCTand invasive coronary angiography with FFR were performed 1 month after STEMI in patients with multivessel disease. Coronary CTA and invasive coronary angiography stenosis >50% were considered obstructive. Lesion-specific ischemia was assumed if FFRCTwas ≤0.80. FFR ≤0.80 was the reference standard. To evaluate the influence of vessel size, the total coronary vessel lumen volume relative to left ventricular mass (volume-to-mass ratio) was calculated and compared with that of patients with stable angina.
RESULTS: The study evaluated 124 nonculprit vessels from 60 patients. Accuracy, sensitivity, and specificity of FFRCTwere 72%, 83%, and 66% versus 64% (p = 0.033), 93% (p = 0.15), and 49% (p < 0.001) for CTA and 72% (p = 1.00), 76% (p = 0.46), and 70% (p = 0.54) for invasive coronary angiography. Following STEMI, median volume-to-mass ratio was lower than in patients with stable angina, 53 versus 65 mm3/g (p = 0.009). In patients with volume-to-mass ratio ≥65 mm3/g (upper tertile) accuracy, sensitivity, and specificity of FFRCTwere all 83% versus 56% (p = 0.009), 75% (p = 0.61), and 44% (p = 0.003) in patients with <49 mm3/g (lower tertile).
CONCLUSIONS: The diagnostic performance of FFRCTfor staged detection of ischemia in STEMI patients with multivessel disease is moderate. STEMI patients have a smaller vessel volume than do patients with stable angina. The diagnostic performance of FFRCTis influenced by the volume-to-mass ratio. This study does not support routine use of FFRCTin the post-STEMI setting. (Assessment of Coronary Stenoses Using Coronary CT-Angiography and Noninvasive Fractional Flow Reserve; NCT01739075).

FAU Authors / FAU Editors

Achenbach, Stephan Prof. Dr. med.
Medizinische Klinik 2 - Kardiologie, Angiologie

External institutions with authors

Aarhus University Hospital / Aarhus Universitetshospital
HeartFlow Inc.
St. Paul's Hospital
University Hospitals of Cleveland / Case Western Reserve University Hospital

How to cite

Gaur, S., Taylor, C.A., Jensen, J.M., Botker, H.E., Christiansen, E.H., Kaltoft, A.K.,... Norgaard, B.L. (2017). FFR Derived From Coronary CT Angiography in Nonculprit Lesions of Patients With Recent STEMI. Journal of the American College of Cardiology : Cardiovascular imaging, 10(4), 424-433. https://dx.doi.org/10.1016/j.jcmg.2016.05.019

Gaur, Sara, et al. "FFR Derived From Coronary CT Angiography in Nonculprit Lesions of Patients With Recent STEMI." Journal of the American College of Cardiology : Cardiovascular imaging 10.4 (2017): 424-433.


Last updated on 2018-10-10 at 11:10