Effect of the ratio of coronary arterial lumen volume to left ventricle myocardial mass derived from coronary CT angiography on fractional flow reserve
Taylor CA, Gaur S, Leipsic J, Achenbach S, Berman DS, Jensen JM, Dey D, Botker HE, Kim HJ, Khem S, Wilk A, Zarins CK, Bezerra H, Lesser J, Ko B, Narula J, Ahmadi A, Ovrehus KA, St Goar F, De Bruyne B, Norgaard BL (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 11
Pages Range: 429-436
Journal Issue: 6
DOI: 10.1016/j.jcct.2017.08.001
Abstract
BACKGROUND: We hypothesize that in patients with suspected coronary artery disease (CAD), lower values of the ratio of total epicardial coronary arterial lumen volume to left ventricular myocardial mass (V/M) result in lower fractional flow reserve (FFR). METHODS: V/M was computed in 238 patients from the NXT trial who underwent coronary computed tomography angiography (CTA), quantitative coronary angiography (QCA) and FFR measurement in 438 vessels. Nitroglycerin was administered prior to CT, QCA and FFR acquisition. The V/M ratio was quantified on a patient-level from CT image data by segmenting the epicardial coronary arterial lumen volume (V) and the left ventricular myocardial mass (M). Calcified and noncalcified plaque volumes were quantified using semi-automated software. RESULTS: The median value of V/M (18.57 mm3/g) was used to define equal groups of low and high V/M patients. Patients with low V/M had greater diameter stenosis by QCA, more plaque and lower FFR (0.80 ± 0.12 vs. 0.87 ± 0.08; P < 0.0001) than those with high V/M. A total of 365 vessels in 202 patients had QCA stenosis ≤50% and measured FFR. In these patients, those with low V/M had higher percent diameter stenosis by QCA, greater total plaque volume and lower FFR (0.81 ± 0.12 vs. 0.88 ± 0.07; P < 0.0001) than those with high V/M. In multivariate logistic regression analysis, V/M was an independent predictor of FFR ≤0.80 (all p-values < 0.001). CONCLUSIONS: Patients with a low V/M ratio have lower FFR overall and in non-obstructive CAD, independent of plaque measures.
Authors with CRIS profile
Involved external institutions
HeartFlow Inc.
United States (USA) (US)
Cedars-Sinai Medical Center
United States (USA) (US)
Abbott Northwestern Hospital
United States (USA) (US)
University Hospitals of Cleveland / Case Western Reserve University Hospital
United States (USA) (US)
Aarhus University
Denmark (DK)
Mount Sinai Hospital (MSH)
Canada (CA)
Monash University
Australia (AU)
El Camino Hospital
United States (USA) (US)
Onze-Lieve-Vrouwziekenhuis (OLV Ziekenhuis, OLVZ)
Belgium (BE)
St. Paul's Hospital
Canada (CA)
United States (USA) (US)
Cedars-Sinai Medical Center
United States (USA) (US)
Abbott Northwestern Hospital
United States (USA) (US)
University Hospitals of Cleveland / Case Western Reserve University Hospital
United States (USA) (US)
Aarhus University
Denmark (DK)
Mount Sinai Hospital (MSH)
Canada (CA)
Monash University
Australia (AU)
El Camino Hospital
United States (USA) (US)
Onze-Lieve-Vrouwziekenhuis (OLV Ziekenhuis, OLVZ)
Belgium (BE)
St. Paul's Hospital
Canada (CA)
How to cite
APA:
Taylor, C.A., Gaur, S., Leipsic, J., Achenbach, S., Berman, D.S., Jensen, J.M.,... Norgaard, B.L. (2017). Effect of the ratio of coronary arterial lumen volume to left ventricle myocardial mass derived from coronary CT angiography on fractional flow reserve. Journal of Cardiovascular Computed Tomography, 11(6), 429-436. https://dx.doi.org/10.1016/j.jcct.2017.08.001
MLA:
Taylor, Charles A., et al. "Effect of the ratio of coronary arterial lumen volume to left ventricle myocardial mass derived from coronary CT angiography on fractional flow reserve." Journal of Cardiovascular Computed Tomography 11.6 (2017): 429-436.
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