Does formalin fixation influence MSCT/CBCT accuracy?
Seidel A, Bergauer B, Lell M, Buder T, von Wilmowsky C, Dach E, Wichmann M, Matta RE (2017)
Publication Type: Journal article
Publication year: 2017
Journal
DOI: 10.1007/s00276-017-1908-x
Abstract
PURPOSE: Advanced imaging modalities, such as multi-slice computed tomography (MSCT) and cone beam computed tomography (CBCT), greatly facilitate diagnostic medicine. In radiological research, it is important to know how accurately a scanned object is visualized, and whether the methodology leads to image distortion. The objective of this study was to evaluate whether formalin fixation impacted the accuracy of virtual 3D bone models generated via CBCT and MSCT using a software-based evaluation method that excluded human measurement errors. METHODS: A head specimen, with and without formalin preservation, was subjected to MSCT and CBCT scans using the manufacturers' predefined scanning protocols. Digital models of the lower jaw were constructed and superimposed with a master model generated based on optical scanning with an industrial non-contact scanner. Means and standard deviations were calculated to assess accuracy, and a t test was used for comparisons between the fixed and unfixed specimens. RESULTS: The extent of discrepancy between the fixed and unfixed specimens was analyzed using a total of 200 points (n = 200) in each specimen state. The mean deviation between states was 0.01 mm for MSCT (at both 80 and 140 kV). Mean values from CBCT at 0.4 voxel did not differ between states. CONCLUSIONS: Our results suggest that formalin fixation of an anatomical specimen does not substantially affect the accuracy of a three-dimensional image generated with CBCT and MSCT. Thus, fixed specimen can be used in future investigations of 3D models without concerns regarding the accuracy.
Authors with CRIS profile
Anna Seidel
Department of Prosthodontics
Bastian Bergauer
Department of Prosthodontics
Thomas Buder
Lehrstuhl für Mikroskopische Anatomie und Molekulare Zellbiologie
Cornelius von Wilmowsky
Department of Oral and Cranio-Maxillofacial Surgery
Manfred Wichmann
Lehrstuhl für Zahn-, Mund- und Kieferheilkunde, insbesondere zahnärztliche Prothetik
Involved external institutions
Austria (AT)How to cite
APA:
Seidel, A., Bergauer, B., Lell, M., Buder, T., von Wilmowsky, C., Dach, E.,... Matta, R.-E. (2017). Does formalin fixation influence MSCT/CBCT accuracy? Surgical and Radiologic Anatomy. https://dx.doi.org/10.1007/s00276-017-1908-x
MLA:
Seidel, Anna, et al. "Does formalin fixation influence MSCT/CBCT accuracy?" Surgical and Radiologic Anatomy (2017).
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