Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts

Scheltens NME, Tijms BM, Koene T, Barkhof F, Teunissen CE, Wolfsgruber S, Wagner M, Kornhuber J, Peters O, Cohn-Sheehy BI, Rabinovici GD, Miller BL, Kramer JH, Scheltens P, Van Der Flier WM (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Alzheimers & Dementia Elsevier Masson

Book Volume: 13

Pages Range: 1226-1236

Journal Issue: 11

DOI: 10.1016/j.jalz.2017.03.002

Abstract

INTRODUCTION: Patients with Alzheimer's disease (AD) show heterogeneity in profile of cognitive impairment. We aimed to identify cognitive subtypes in four large AD cohorts using a data-driven clustering approach. METHODS: We included probable AD dementia patients from the Amsterdam Dementia Cohort (n = 496), Alzheimer's Disease Neuroimaging Initiative (n = 376), German Dementia Competence Network (n = 521), and University of California, San Francisco (n = 589). Neuropsychological data were clustered using nonnegative matrix factorization. We explored clinical and neurobiological characteristics of identified clusters. RESULTS: In each cohort, a two-clusters solution best fitted the data (cophenetic correlation >0.9): one cluster was memory-impaired and the other relatively memory spared. Pooled analyses showed that the memory-spared clusters (29%-52% of patients) were younger, more often apolipoprotein E (APOE) ɛ4 negative, and had more severe posterior atrophy compared with the memory-impaired clusters (all P < .05). CONCLUSIONS: We could identify two robust cognitive clusters in four independent large cohorts with distinct clinical characteristics.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

Vrije Universiteit Amsterdam (VU) / University Amsterdam NL Netherlands (NL) Rheinische Friedrich-Wilhelms-Universität Bonn DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) University of California San Francisco (UCSF) US United States (USA) (US)

How to cite

APA:

Scheltens, N.M.E., Tijms, B.M., Koene, T., Barkhof, F., Teunissen, C.E., Wolfsgruber, S.,... Van Der Flier, W.M. (2017). Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts. Alzheimers & Dementia, 13(11), 1226-1236. https://doi.org/10.1016/j.jalz.2017.03.002

MLA:

Scheltens, Nienke M. E., et al. "Cognitive subtypes of probable Alzheimer's disease robustly identified in four cohorts." Alzheimers & Dementia 13.11 (2017): 1226-1236.

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