Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival

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Details zur Publikation

Autor(en): Arnold M, Bach C, Heinemann FM, Horn PA, Ziemann M, Lachmann N, Muehlbacher A, Dick A, Ender A, Thammanichanond D, Schaub S, Honger G, Fischer GF, Mytilineos J, Hallensleben M, Hitzler WE, Seidl C, Spriewald BM
Zeitschrift: International Journal of Immunogenetics
Jahr der Veröffentlichung: 2018
ISSN: 1744-3121


Abstract

We reported previously on the widespread occurrence of anti-HLA alloantibodies of the IgA isotype (anti-HLA IgA) in the sera of solid-organ re-transplantation (re-tx) candidates (Arnold et al., ). Specifically focussing on kidney re-tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti-HLA IgA on graft survival. We observed frequent concurrence of anti-HLA IgA and anti-HLA IgG in 27% of our multicenter collective of 694 kidney re-tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (TTD 77 months) compared to patients carrying either anti-HLA IgG or IgA (TTD 102 and 94 months, respectively). In addition, donor specificity of anti-HLA IgA had a significant negative impact on graft survival (TTD 74 months) in our study. Taken together, our data strongly indicate that presence of anti-HLA IgA, in particular in conjunction with anti-HLA-IgG, in sera of kidney re-tx patients is associated with negative transplantation outcome.


FAU-Autoren / FAU-Herausgeber

Bach, Christian Dr. rer. nat.
Medizinische Klinik 5 - Hämatologie und Internistische Onkologie


Autor(en) der externen Einrichtung(en)
Charité - Universitätsmedizin Berlin
DRK-Blutspendedienst Baden-Württemberg - Hessen / German Red Cross Blood Donor Service Baden-Wuerttemberg – Hessen
Hannover Medical School / Medizinische Hochschule Hannover (MHH)
Johannes Gutenberg-Universität Mainz
Katharinenhospital Stuttgart
Ludwig Boltzmann Gesellschaft
Ludwig-Maximilians-Universität (LMU)
Mahidol University / มหาวิทยาลัยมหิดล
Medizinische Universität Wien
Universität Basel
Universitätsklinikum Essen
Universitätsklinikum Schleswig-Holstein (UKSH)
Universitätsklinikum Ulm
Universitätsspital Basel


Zitierweisen

APA:
Arnold, M., Bach, C., Heinemann, F.M., Horn, P.A., Ziemann, M., Lachmann, N.,... Spriewald, B.M. (2018). Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival. International Journal of Immunogenetics. https://dx.doi.org/10.1111/iji.12363

MLA:
Arnold, Martin, et al. "Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival." International Journal of Immunogenetics (2018).

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Zuletzt aktualisiert 2018-12-11 um 13:08