Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

Roedel F, Fournier C, Wiedemann J, Merz F, Gaipl U, Frey B, Keilholz L, Seegenschmiedt MH, Roedel C, Hehlgans S (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 8

DOI: 10.3389/fimmu.2017.00519

Abstract

For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma. Although RT has become an established and effective option in the management of these diseases, experimental studies to illustrate cellular composites and factors involved remain to be elucidated. More recent findings, however, indicate the involvement of radiation-sensitive targets like mitotic fibroblasts/myofibroblasts as well as inflammatory cells. Radiation-related molecular mechanisms affecting these target cells include the production of free radicals to hamper proliferative activity and interference with growth factors and cytokines. Moreover, an impairment of activated immune cells involved in both myofibroblast proliferative and inflammatory processes may further contribute to the clinical effects. We here aim at briefly describing mechanisms contributing to a modulation of proliferative and inflammatory processes and to summarize current concepts of treating hyperproliferative diseases by low and moderate doses of ionizing radiation.

Authors with CRIS profile

Udo Gaipl Department of Radiation Oncology Benjamin Frey Department of Radiation Oncology

Involved external institutions

Goethe-Universität Frankfurt am Main DE Germany (DE) GSI Helmholtzzentrum für Schwerionenforschung GmbH DE Germany (DE) Klinikum Bayreuth DE Germany (DE) Strahlenzentrum Hamburg MVZ DE Germany (DE)

How to cite

APA:

Roedel, F., Fournier, C., Wiedemann, J., Merz, F., Gaipl, U., Frey, B.,... Hehlgans, S. (2017). Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases. Frontiers in Immunology, 8. https://dx.doi.org/10.3389/fimmu.2017.00519

MLA:

Roedel, Franz, et al. "Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases." Frontiers in Immunology 8 (2017).

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