Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Roedel F, Fournier C, Wiedemann J, Merz F, Gaipl U, Frey B, Keilholz L, Seegenschmiedt MH, Roedel C, Hehlgans S
Zeitschrift: Frontiers in Immunology
Jahr der Veröffentlichung: 2017
Band: 8
ISSN: 1664-3224


For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma. Although RT has become an established and effective option in the management of these diseases, experimental studies to illustrate cellular composites and factors involved remain to be elucidated. More recent findings, however, indicate the involvement of radiation-sensitive targets like mitotic fibroblasts/myofibroblasts as well as inflammatory cells. Radiation-related molecular mechanisms affecting these target cells include the production of free radicals to hamper proliferative activity and interference with growth factors and cytokines. Moreover, an impairment of activated immune cells involved in both myofibroblast proliferative and inflammatory processes may further contribute to the clinical effects. We here aim at briefly describing mechanisms contributing to a modulation of proliferative and inflammatory processes and to summarize current concepts of treating hyperproliferative diseases by low and moderate doses of ionizing radiation.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Frey, Benjamin PD Dr.
Gaipl, Udo Prof. Dr.

Einrichtungen weiterer Autorinnen und Autoren

Goethe-Universität Frankfurt am Main
GSI Helmholtzzentrum für Schwerionenforschung GmbH
Klinikum Bayreuth
Strahlenzentrum Hamburg MVZ


Roedel, F., Fournier, C., Wiedemann, J., Merz, F., Gaipl, U., Frey, B.,... Hehlgans, S. (2017). Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases. Frontiers in Immunology, 8.

Roedel, Franz, et al. "Basics of Radiation Biology When Treating Hyperproliferative Benign Diseases." Frontiers in Immunology 8 (2017).


Zuletzt aktualisiert 2019-17-04 um 08:17