Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic

Journal article


Publication Details

Author(s): O'Bryant SE, Mielke MM, Rissman RA, Lista S, Vanderstichele H, Zetterberg H, Lewczuk P, Posner H, Hall J, Johnson L, Fong YL, Luthman J, Jeromin A, Batrla-Utermann R, Villarreal A, Britton G, Snyder PJ, Henriksen K, Grammas P, Gupta V, Martins R, Hampel H
Journal: Alzheimers & Dementia
Publication year: 2017
Volume: 13
Journal issue: 1
Pages range: 45-58
ISSN: 1552-5260


Abstract

The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.


FAU Authors / FAU Editors

Lewczuk, Piotr Prof. Dr.
Psychiatrische und Psychotherapeutische Klinik


External institutions with authors

ADx NeuroSciences
AXA Research Fund
Brown University
Edith Cowan University
Instituto de Investigaciones Científicas y Servicios de Alta Tecnología AIP (INDICASAT AIP)
Johnson & Johnson Services, Inc.
Mayo Clinic
Nordic Bioscience
Pfizer, Inc.
Quanterix Corporation
Roche Diagnostics (Schweiz) AG
Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset
University of California, San Diego
University of North Texas (UNT)
Univ. Rhode Island


How to cite

APA:
O'Bryant, S.E., Mielke, M.M., Rissman, R.A., Lista, S., Vanderstichele, H., Zetterberg, H.,... Hampel, H. (2017). Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers & Dementia, 13(1), 45-58. https://dx.doi.org/10.1016/j.jalz.2016.09.014

MLA:
O'Bryant, Sid E., et al. "Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic." Alzheimers & Dementia 13.1 (2017): 45-58.

BibTeX: 

Last updated on 2018-12-11 at 11:23