Contact allergy to preservatives: ESSCA* results with the baseline series, 2009-2012

Gimenez-Arnau AM, Deza G, Bauer A, Johnston GA, Mahler V, Schuttelaar ML, Sanchez-Perez J, Silvestre JF, Wilkinson M, Uter W (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Journal of the European Academy of Dermatology and Venereology Wiley-Blackwell

Book Volume: 31

Pages Range: 664-671

Journal Issue: 4

DOI: 10.1111/jdv.14063

Abstract

BACKGROUND: Allergic contact dermatitis caused by biocides is common and causes significant patient morbidity. OBJECTIVE: To describe the current frequency and pattern of patch test reactivity to biocide allergens included in the baseline series of most European countries. METHODS: Data collected by the European Surveillance System on Contact Allergies (ESSCA) network between 2009 and 2012 from 12 European countries were analysed. RESULTS: Methylisothiazolinone 0.2% aq. produced the highest prevalence of sensitization during the study period, with an overall prevalence of 4.5%. The mixture methylchloroisothiazolinone /methylisothiazolinone tested at 0.02% aq. followed closely, with 4.1% of positive reactions. Other preservatives with lower rates of sensitization, but still over 1%, include methyldibromo glutaronitrile (MDBGN) 0.5% pet. and iodopropynyl butylcarbamate (IPBC) 0.2% pet. Formaldehyde releasers and parabens yielded less than 1% positive reactions during the study period. Some regional differences in the prevalence of contact allergy to biocides among European countries were observed. CONCLUSIONS: Contact allergy to biocides is common throughout Europe, and regional differences could be explained by differences in exposure or characteristics of the population tested. Timely regulatory action for isothiazolinones is required. Although MDBGN is banned from cosmetics products since 2005, sensitization prevalence has not appeared to plateau. IPBC is an emerging allergen with an increasing prevalence over the last few years, and its inclusion in the European baseline series may be appropriate.

Authors with CRIS profile

Vera Mahler Medizinische Fakultät Wolfgang Uter Professur für Epidemiologie

Additional Organisation(s)

Department of Dermatology

Involved external institutions

Chapel Allerton Hospital GB United Kingdom (GB) Hospital General Universitario de Alicante ES Spain (ES) Hospital Universitario de La Princesa ES Spain (ES) University of Leicester GB United Kingdom (GB) University of Groningen / Rijksuniversiteit Groningen NL Netherlands (NL) Technische Universität Dresden DE Germany (DE) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona ES Spain (ES)

How to cite

APA:

Gimenez-Arnau, A.M., Deza, G., Bauer, A., Johnston, G.A., Mahler, V., Schuttelaar, M.-L.,... Uter, W. (2017). Contact allergy to preservatives: ESSCA* results with the baseline series, 2009-2012. Journal of the European Academy of Dermatology and Venereology, 31(4), 664-671. https://doi.org/10.1111/jdv.14063

MLA:

Gimenez-Arnau, A. M., et al. "Contact allergy to preservatives: ESSCA* results with the baseline series, 2009-2012." Journal of the European Academy of Dermatology and Venereology 31.4 (2017): 664-671.

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