Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis

Journal article


Publication Details

Author(s): Veronese N, Sergi G, Stubbs B, Bourdel-Marchasson I, Tessier D, Sieber C, Strandberg T, Gillain S, Barbagallo M, Crepaldi G, Maggi S, Manzato E
Journal: European Geriatric Medicine
Publisher: ELSEVIER MASSON, CORPORATION OFFICE
Publication year: 2017
Volume: 8
Journal issue: 2
Pages range: 117-122
ISSN: 1878-7649


Abstract

Background/aim: Deficiency of acetyl-L-carnitine (ALC) and L-carnitine (LC) appears to play a role in peripheral diabetic neuropathy, although the evidence in humans is still limited. We conducted a systematic review and meta-analysis investigating the effect of ALC on pain and electromyographic parameters in people with diabetic neuropathy.Methods: A literature search in major databases, without language restriction, was undertaken. Eligible studies were randomized controlled trials (RCTs) or pre-and post-test studies. The effect of ALC supplementation on pain perception and electromyographic parameters in patients with diabetic neuropathy was compared vs. a control group (RCTs). The effect of ALC/LC on electromyographic parameters were also calculated vs. baseline values. Standardized mean differences (SMD) and 95% confidence intervals (CIs) were used for summarizing outcomes.Results: Six articles, with a total of 711 diabetic participants, were included. Three RCTs (340 treated with ALC vs. 203 placebo and 115 with methylcobalamine) showed that ALC reduces pain perception (SMD = -0.45; 95% CI: -0.86 to -0.04; P = 0.03; I-2 = 85%). Compared to controls, ALC supplementation improved nerve conduction velocity and amplitude response for ulnar nerve (both sensory and motor component). Compared to baseline values, ALC/LC supplementation improved nerve conduction velocity for all the sensory and motor nerves (except ulnar and peroneal) investigated and the amplitude of all nerves. The onset of adverse events was generally limited to minor side effects.Conclusion: ALC appears to be effective in reducing pain due to diabetic neuropathy compared to active or placebo controls and improving electromyographic parameters in these patients. (C) 2017 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.


FAU Authors / FAU Editors

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)


External institutions with authors

Centre Hospitalier Universitaire de Bordeaux / CHU Bordeaux
Centre Hospitalier Universitaire de Liège (CHU Liège)
Consiglio Nazionale delle Ricerche (CNR)
Helsingin yliopisto / University of Helsinki
South London and Maudsley NHS Foundation Trust
Università degli Studi di Palermo
Université de Sherbrooke
University of Padua


How to cite

APA:
Veronese, N., Sergi, G., Stubbs, B., Bourdel-Marchasson, I., Tessier, D., Sieber, C.,... Manzato, E. (2017). Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis. European Geriatric Medicine, 8(2), 117-122. https://dx.doi.org/10.1016/j.eurger.2017.01.002

MLA:
Veronese, N., et al. "Effect of acetyl-l-carnitine in the treatment of diabetic peripheral neuropathy: A systematic review and meta-analysis." European Geriatric Medicine 8.2 (2017): 117-122.

BibTeX: 

Last updated on 2018-09-11 at 16:08