Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI

Journal article


Publication Details

Author(s): Czock D, Schwenger V, Kindgen-Milles D, Joannidis M, John S, Schmitz M, Joerres A, Zarbock A, Oppert M, Kielstein JT, Willam C
Journal: Medizinische Klinik - Intensivmedizin und Notfallmedizin
Publication year: 2018
Volume: 113
Journal issue: 5
Pages range: 384-392
ISSN: 2193-6218
eISSN: 2193-6226


Abstract

BACKGROUND: Many anti-infective drugs require dose adjustments in critically ill patients with acute kidney injury (AKI) and renal replacement therapy, in order to achieve adequate therapeutic drug concentrations.
OBJECTIVES: The fundamental pharmacokinetic and pharmacodynamic principles of drug dose adjustment are presented. Recommendations on anti-infective drug dosage in intensive care are provided.
MATERIALS AND METHODS: We established dose recommendations of selected anti-infective drugs based on information in the summary of product characteristics, published studies and recommendations, pharmacokinetic and pharmacodynamic considerations, and the experience and expert opinion of the authors.
RESULTS: Out of a total of 37 anti-infective drugs (31 antibiotics, 2 antivirals, 4 antifungals) 8 can be administered independent of renal function. For 29 anti-infective drugs, a specific recommendation on drug dosage could be made in case of intermittent hemodialysis and for 24 anti-infective drugs in case of continuous hemo(dia)filtration.
CONCLUSIONS: Recommendations on dosing of important anti-infective drugs in critically ill patients with AKI and renal replacement therapy are provided.


FAU Authors / FAU Editors

Willam, Carsten Prof. Dr.
Medizinische Klinik 4 - Nephrologie und Hypertensiologie


External institutions with authors

Heinrich-Heine-Universität Düsseldorf
Klinikum Ernst von Bergmann
Klinikum Stuttgart
Krankenhaus Köln-Merheim - Klinikum der Universität Witten/Herdecke
Medizinische Universität Innsbruck
Städtisches Klinikum Braunschweig
Städtisches Klinikum Solingen
Universitätsklinikum Heidelberg
Universitätsklinikum Münster


How to cite

APA:
Czock, D., Schwenger, V., Kindgen-Milles, D., Joannidis, M., John, S., Schmitz, M.,... Willam, C. (2018). Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI. Medizinische Klinik - Intensivmedizin und Notfallmedizin, 113(5), 384-392. https://dx.doi.org/10.1007/s00063-018-0416-z

MLA:
Czock, D., et al. "Dose adjustment of anti-infective drugs in patients with renal failure and renal replacement therapy in intensive care medicine : Recommendations from the renal section of the DGIIN, ÖGIAIN and DIVI." Medizinische Klinik - Intensivmedizin und Notfallmedizin 113.5 (2018): 384-392.

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Last updated on 2018-12-11 at 11:08