Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases
Schaible HG, Chang HD, Graessel S, Haibel H, Heß A, Kamradt T, Radbruch A, Schett G, Stein C, Straub RH (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 77
Pages Range: 24-30
Journal Issue: Suppl 1
DOI: 10.1007/s00393-018-0459-9
Abstract
BACKGROUND: The research consortium Neuroimmunology and Pain (Neuroimpa) explores the importance of the relationships between the immune system and the nervous system in musculoskeletal diseases for the generation of pain and for the course of fracture healing and arthritis. MATERIAL AND METHODS: The spectrum of methods includes analyses at the single cell level, in vivo models of arthritis and fracture healing, imaging studies on brain function in animals and humans and analysis of data from patients. RESULTS: Proinflammatory cytokines significantly contribute to the generation of joint pain through neuronal cytokine receptors. Immune cells release opioid peptides which activate opioid receptors at peripheral nociceptors and thereby evoke hypoalgesia. The formation of new bone after fractures is significantly supported by the nervous system. The sympathetic nervous system promotes the development of immune-mediated arthritis. The studies show a significant analgesic potential of the neutralization of proinflammatory cytokines and of opioids which selectively inhibit peripheral neurons. Furthermore, they show that the modulation of neuronal mechanisms can beneficially influence the course of musculoskeletal diseases. DISCUSSION: Interventions in the interactions between the immune system and the nervous system hold a great therapeutic potential for the treatment of musculoskeletal diseases and pain.
Authors with CRIS profile
Involved external institutions
Friedrich-Schiller-Universität Jena
Germany (DE)
Deutsches Rheuma-Forschungszentrum (DRFZ)
Germany (DE)
Universitätsklinikum Regensburg
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
Germany (DE)
Deutsches Rheuma-Forschungszentrum (DRFZ)
Germany (DE)
Universitätsklinikum Regensburg
Germany (DE)
Charité - Universitätsmedizin Berlin
Germany (DE)
How to cite
APA:
Schaible, H.-G., Chang, H.-D., Graessel, S., Haibel, H., Heß, A., Kamradt, T.,... Straub, R.H. (2018). Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases. Zeitschrift für Rheumatologie, 77(Suppl 1), 24-30. https://dx.doi.org/10.1007/s00393-018-0459-9
MLA:
Schaible, H-G., et al. "Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases." Zeitschrift für Rheumatologie 77.Suppl 1 (2018): 24-30.
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