Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Strick R, Strissel P, Baylin SB, Chiappinelli KB (2016)

Publication Type: Journal article

Publication year: 2016

Journal

OncoImmunology Taylor & Francis

Book Volume: 5

Journal Issue: 5

DOI: 10.1080/2162402X.2015.1122160

Abstract

Loss of DNA methylation can activate endogenous retroviral expression and dsRNA in cancer cells. This leads to induction of toll-like receptor signaling stimulating an antiviral interferon response. Recent findings provide a therapeutic rationale for combining DNA methylation inhibitors with blockage of immune checkpoint proteins to fight cancer.

Authors with CRIS profile

Reiner Strick Medizinische Fakultät Pamela Strissel Medizinische Fakultät

Additional Organisation(s)

Lehrstuhl für Geburtshilfe und Frauenheilkunde

Involved external institutions

Johns Hopkins Hospital US United States (USA) (US)

How to cite

APA:

Strick, R., Strissel, P., Baylin, S.B., & Chiappinelli, K.B. (2016). Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors. OncoImmunology, 5(5). https://dx.doi.org/10.1080/2162402X.2015.1122160

MLA:

Strick, Reiner, et al. "Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors." OncoImmunology 5.5 (2016).

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