Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme

Journal article


Publication Details

Author(s): Kiefer A, Bogdan C, Melichar VO
Journal: BMC Pulmonary Medicine
Publication year: 2018
Volume: 18
Journal issue: 1
ISSN: 1471-2466


Abstract

BACKGROUND: In individuals with cystic fibrosis (CF), colonization with methicillin-resistant Staphylococcus aureus (MRSA) was reported to be associated with a deterioration of pulmonary disease as reflected by an accelerated decline in lung function. Thus, an early eradication of MRSA could be beneficial in these patients. Here, we report on an intensified MRSA eradication protocol.
METHODS: Since 2012 a protocol for the eradication of newly acquired MRSA has been used in our CF Clinic, combining oral rifampicin and fusidic acid, inhaled vancomycin, nasal mupirocin, local antiseptic treatment and hygienic directives all of which are applied for only 7 days during an inpatient hospital stay.
RESULTS: Since 2012 seven patients (3 male, 4 female; age range 4 to 30 years) newly acquired MRSA. In 6 of the 7 patients (86%) successful eradication of MRSA was achieved upon first treatment using the protocol described above. In one patient a second course of treatment was performed which, however, also failed to eliminate the colonizing MRSA.
CONCLUSIONS: Our protocol led to an eradication rate of 86%. The impact of each individual component of the protocol remains to be determined.


FAU Authors / FAU Editors

Bogdan, Christian Prof. Dr.
Lehrstuhl für Mikrobiologie und Infektionsimmunologie
Kiefer, Alexander
Lehrstuhl für Klinische Nuklearmedizin


How to cite

APA:
Kiefer, A., Bogdan, C., & Melichar, V.O. (2018). Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme. BMC Pulmonary Medicine, 18(1). https://dx.doi.org/10.1186/s12890-018-0588-6

MLA:
Kiefer, Alexander, Christian Bogdan, and Volker O. Melichar. "Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme." BMC Pulmonary Medicine 18.1 (2018).

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Last updated on 2019-05-01 at 10:10