The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Bos I, Vos SJ, Froelich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Ruether E, Engelborghs S, Niemantsverdriet E, De Roeck EE, Tsolaki M, Freund-Levim Y, Johannsen P, Vandenberghe R, Lleo A, Alcolea D, Frisoni GB, Galluzzi S, Nobili F, Morbelli S, Drzezga A, Didic M, Van Berckel BN, Salmon E, Bastin C, Dauby S, Santana I, Baldeiras I, De Mendonca A, Silva D, Wallin A, Nordlund A, Coloma PM, Wientzek A, Alexander M, Novak GP, Gordon MF, Wallin AK, Hampel H, Soininen H, Herukka SK, Scheltens P, Verhey FR, Visser PJ
Zeitschrift: Neurobiology of Aging
Jahr der Veröffentlichung: 2017
Band: 56
Seitenbereich: 33-40
ISSN: 0197-4580


Abstract

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Kornhuber, Johannes Prof. Dr. med.
Lehrstuhl für Psychiatrie und Psychotherapie


Einrichtungen weiterer Autorinnen und Autoren

Aristotle University of Thessaloniki
Centre Hospitalier Universitaire de Liège (CHU Liège)
Charité - Universitätsmedizin Berlin
Copenhagen University Hospital
Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG)
Georg-August-Universität Göttingen
Hôpital de la Timone
Hospital de la Santa Creu i Sant Pau
Hospital Network Antwerp / Ziekenhuis Netwerk Antwerpen (ZNA)
IRCCS Fatebenefratelli - Brescia
Karolinska Institute
Maastricht University
Rheinische Friedrich-Wilhelms-Universität Bonn
Ruprecht-Karls-Universität Heidelberg
Universidade de Coimbra
Universität Köln
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of Antwerp / Universiteit Antwerpen
University of Eastern Finland
University of Genova / Università degli Studi di Genova
University of Liège (ULg) / Université de Liège
Vrije Universiteit Amsterdam (VU) / University Amsterdam


Zitierweisen

APA:
Bos, I., Vos, S.J., Froelich, L., Kornhuber, J., Wiltfang, J., Maier, W.,... Visser, P.J. (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40. https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.034

MLA:
Bos, Isabelle, et al. "The frequency and influence of dementia risk factors in prodromal Alzheimer's disease." Neurobiology of Aging 56 (2017): 33-40.

BibTeX: 

Zuletzt aktualisiert 2018-19-11 um 16:08