The frequency and influence of dementia risk factors in prodromal Alzheimer's disease

Bos I, Vos SJ, Froelich L, Kornhuber J, Wiltfang J, Maier W, Peters O, Ruether E, Engelborghs S, Niemantsverdriet E, De Roeck EE, Tsolaki M, Freund-Levim Y, Johannsen P, Vandenberghe R, Lleo A, Alcolea D, Frisoni GB, Galluzzi S, Nobili F, Morbelli S, Drzezga A, Didic M, Van Berckel BN, Salmon E, Bastin C, Dauby S, Santana I, Baldeiras I, De Mendonca A, Silva D, Wallin A, Nordlund A, Coloma PM, Wientzek A, Alexander M, Novak GP, Gordon MF, Wallin AK, Hampel H, Soininen H, Herukka SK, Scheltens P, Verhey FR, Visser PJ (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 56

Pages Range: 33-40

DOI: 10.1016/j.neurobiolaging.2017.03.034

Abstract

We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline. Depression, obesity, and hypercholesterolemia occurred more often in individuals with low-AD-likelihood, compared with those with a high-AD-likelihood. Only alcohol use increased the risk of cognitive decline, regardless of AD pathology. These results suggest that traditional risk factors for AD are not associated with prodromal AD or with progression to dementia, among subjects with mild cognitive impairment. Future studies should validate these findings and determine whether risk factors might be of influence at an earlier stage (i.e., preclinical) of AD.

Authors with CRIS profile

Involved external institutions

Hospital de la Santa Creu i Sant Pau Spain (ES) University of Genova / Università degli Studi di Genova Italy (IT) Universität zu Köln Germany (DE) Hôpital de la Timone France (FR) Vrije Universiteit Amsterdam (VU) / University Amsterdam Netherlands (NL) University of Liège (ULg) / Université de Liège Belgium (BE) Maastricht University Netherlands (NL) Ruprecht-Karls-Universität Heidelberg Germany (DE) Georg-August-Universität Göttingen Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Hospital Network Antwerp / Ziekenhuis Netwerk Antwerpen (ZNA) Belgium (BE) University of Antwerp / Universiteit Antwerpen Belgium (BE) Aristotle University of Thessaloniki Greece (GR) Karolinska Institute Sweden (SE) Copenhagen University Hospital Denmark (DK) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) IRCCS Fatebenefratelli - Brescia Italy (IT) Centre Hospitalier Universitaire de Liège (CHU Liège) Belgium (BE) Universidade de Coimbra Portugal (PT) University of Eastern Finland Finland (FI)

How to cite

APA:

Bos, I., Vos, S.J., Froelich, L., Kornhuber, J., Wiltfang, J., Maier, W.,... Visser, P.J. (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40. https://dx.doi.org/10.1016/j.neurobiolaging.2017.03.034

MLA:

Bos, Isabelle, et al. "The frequency and influence of dementia risk factors in prodromal Alzheimer's disease." Neurobiology of Aging 56 (2017): 33-40.

BibTeX: Download