The epidemic of methylisothiazolinone: a European prospective study
Schwensen JF, Uter W, Bruze M, Svedman C, Goossens A, Wilkinson M, Gimenez Arnau A, Goncalo M, Andersen KE, Paulsen E, Agner T, Foti C, Aalto-Korte K, Mcfadden J, White I, Johansen JD (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 76
Pages Range: 272-279
Journal Issue: 5
DOI: 10.1111/cod.12733
Abstract
BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required. OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy. METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.). RESULTS: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms. CONCLUSION: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.
Authors with CRIS profile
Involved external institutions
Guy's and St Thomas' (NHS Foundation Trust)
United Kingdom (GB)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
Finnish Institute of Occupational Health (FIOH) / Työterveyslaitos (TTL)
Finland (FI)
University of Copenhagen
Denmark (DK)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Universidade de Coimbra
Portugal (PT)
Leeds Teaching Hospitals NHS Trust
United Kingdom (GB)
University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro
Italy (IT)
Lund University / Lunds universitet
Sweden (SE)
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
Belgium (BE)
United Kingdom (GB)
University of Southern Denmark / Syddansk Universitet
Denmark (DK)
Finnish Institute of Occupational Health (FIOH) / Työterveyslaitos (TTL)
Finland (FI)
University of Copenhagen
Denmark (DK)
Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona
Spain (ES)
Universidade de Coimbra
Portugal (PT)
Leeds Teaching Hospitals NHS Trust
United Kingdom (GB)
University of Bari Aldo Moro / Università degli Studi di Bari Aldo Moro
Italy (IT)
Lund University / Lunds universitet
Sweden (SE)
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
Belgium (BE)
How to cite
APA:
Schwensen, J.F., Uter, W., Bruze, M., Svedman, C., Goossens, A., Wilkinson, M.,... Johansen, J.D. (2017). The epidemic of methylisothiazolinone: a European prospective study. Contact Dermatitis, 76(5), 272-279. https://doi.org/10.1111/cod.12733
MLA:
Schwensen, Jakob F., et al. "The epidemic of methylisothiazolinone: a European prospective study." Contact Dermatitis 76.5 (2017): 272-279.
BibTeX: Download