Pediatric reference intervals for alkaline phosphatase

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Zierk J, Arzideh F, Haeckel R, Cario H, Fruehwald MC, Gross HJ, Gscheidmeier T, Hoffmann R, Krebs A, Lichtinghagen R, Neumann M, Ruf HG, Steigerwald U, Streichert T, Rascher W, Metzler M, Rauh M
Zeitschrift: Clinical Chemistry and Laboratory Medicine
Jahr der Veröffentlichung: 2017
Band: 55
Heftnummer: 1
Seitenbereich: 102-110
ISSN: 1434-6621


BACKGROUND: Interpretation of alkaline phosphatase activity in children is challenging due to extensive changes with growth and puberty leading to distinct sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics and seem reasonable for an analyte as closely linked to growth as alkaline phosphatase. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, resulting in limitations when clinical decisions are based on alkaline phosphatase activity.
METHODS: We applied an indirect method to generate percentile charts for alkaline phosphatase activity using clinical laboratory data collected during the clinical care of patients. A total of 361,405 samples from 124,440 patients from six German tertiary care centers and one German laboratory service provider measured between January 2004 and June 2015 were analyzed. Measurement of alkaline phosphatase activity was performed on Roche Cobas analyzers using the IFCC's photometric method.
RESULTS: We created percentile charts for alkaline phosphatase activity in girls and boys from birth to 18 years which can be used as reference intervals. Additionally, data tables of age- and sex-specific percentile values allow the incorporation of these results into laboratory information systems.
CONCLUSIONS: The percentile charts provided enable the appropriate differential diagnosis of changes in alkaline phosphatase activity due to disease and changes due to physiological development. After local validation, integration of the provided percentile charts into result reporting facilitates precise assessment of alkaline phosphatase dynamics in pediatrics.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Metzler, Markus PD Dr.
Professur für Kinder- und Jugendmedizin mit dem Schwerpunkt Pädiatrische Onkologie und Hämatologie
Rascher, Wolfgang Prof. Dr. med.
Kinder- und Jugendklinik
Rauh, Manfred Prof. Dr.
Kinder- und Jugendklinik
Zierk, Jakob Dr. med.
Kinder- und Jugendklinik

Einrichtungen weiterer Autorinnen und Autoren

Julius-Maximilians-Universität Würzburg
Klinikum Augsburg
Klinikverbund Bremen
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
MVZ Labor PD Dr. Volkmann und Kollegen
Universität Bremen
Universitätsklinikum Heidelberg
Universitätsklinikum Ulm
Universitätsklinikum Würzburg


Zierk, J., Arzideh, F., Haeckel, R., Cario, H., Fruehwald, M.C., Gross, H.-J.,... Rauh, M. (2017). Pediatric reference intervals for alkaline phosphatase. Clinical Chemistry and Laboratory Medicine, 55(1), 102-110.

Zierk, Jakob, et al. "Pediatric reference intervals for alkaline phosphatase." Clinical Chemistry and Laboratory Medicine 55.1 (2017): 102-110.


Zuletzt aktualisiert 2018-24-10 um 08:38