Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy
Tzabazis A, Wiernik M, Wielopolski J, Sperling W, Ihmsen H, Schmitt HJ, Münster T (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 17
Journal Issue: 1
DOI: 10.1186/s12871-017-0412-5
Abstract
BACKGROUND: Seizure duration in electroconvulsive therapy (ECT) is positively related with patients' outcome. This study sought to investigate the impact of anesthetic management on seizure duration, and the impact of selected drugs (theophylline, remifentanil, S-ketamine) on seizure duration. METHODS: Retrospective analysis of all patients undergoing ECT at our institution from January 2011 to April 2012 was performed based on electronic medical chart and review of existing quality improvement data. Patient data (N = 78), including gender, age, height, weight, and administered drugs, energy levels, and electroencephalic seizure duration were analyzed. Statistical analysis was performed using a generalized linear model. RESULTS: A total of 78 patients (male = 39, female = 39, age 51 ± 12 years) were included. Average number of session was 10 ± 6 (1-30). In our patient population, theophylline administration was the only parameter, which significantly prolonged seizure duration, whereas S-ketamine, remifentanil, thiopental, age, sex, session or energy level had no significant effect. CONCLUSION: Theophylline can be a useful adjunct for patients with inadequate seizure duration. If there is a concomitant beneficial effect on patients' outcome needs to be investigated in further studies.
Authors with CRIS profile
Michaela Wiernik
Department of Anaesthesiology
Harald Ihmsen
Department of Anaesthesiology
Tino Münster
Department of Anaesthesiology
Involved external institutions
United States (USA) (US)
Switzerland (CH)How to cite
APA:
Tzabazis, A., Wiernik, M., Wielopolski, J., Sperling, W., Ihmsen, H., Schmitt, H.J., & Münster, T. (2017). Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy. BMC Anesthesiology, 17(1). https://dx.doi.org/10.1186/s12871-017-0412-5
MLA:
Tzabazis, Alexander, et al. "Intravenous theophylline is the most effective intervention to prolong EEG seizure duration in patients undergoing electroconvulsive therapy." BMC Anesthesiology 17.1 (2017).
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