Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study

Journal article


Publication Details

Author(s): Verlaan S, Maier AB, Bauer JM, Bautmans I, Brandt K, Donini LM, Maggio M, Mcmurdo MET, Mets T, Seal C, Wijers SLJ, Sieber C, Boirie Y, Cederholm T
Journal: Clinical Nutrition
Publisher: CHURCHILL LIVINGSTONE
Publication year: 2018
Volume: 37
Journal issue: 2
Pages range: 551-557
ISSN: 0261-5614


Abstract

Background: Inadequate nutritional intake and altered response of aging muscles to anabolic stimuli from nutrients contribute to the development of sarcopenia. Nutritional interventions show inconsistent results in sarcopenic older adults, which might be influenced by their basal nutritional status.Objective: To test if baseline serum 25-hydroxyvitamin D (25(OH)D) concentrations and dietary protein intake influenced changes in muscle mass and function in older adults who received nutritional intervention.Methods and design: Post-hoc analysis was performed in the PROVIDE study that was a randomized controlled, double blind trial among 380 sarcopenic older adults. This study showed that those who received a vitamin D and leucine-enriched whey protein medical nutrition drink for 13 weeks gained more appendicular muscle mass (aMM), and improved lower-extremity function as assessed by the chair stand test compared with controls. To define low and high groups, a baseline serum concentration of 50 nmol/L 25(OH)D and baseline dietary protein intake of 1.0 g/kg/d were used as cut offs.Results: At baseline, participants with lower 25(OH)D concentrations showed lower muscle mass, strength and function compared with participants with a high 25(OH)D, while the group with lower protein intake (g/kg/day) had more muscle mass at baseline compared with the participants with higher protein intake. Participants with higher baseline 25(OH)D concentrations and dietary protein intake had, independent of other determinants, greater gain in appendicular muscle mass, skeletal muscle index (aMM/h(2)), and relative appendicular muscle mass (aMM/body weight x 100%) in response to the nutritional intervention. There was no effect modification of baseline 25(OH)D status or protein intake on change in chair-stand test.Conclusions: Sufficient baseline levels of 25(OH)D and protein intake may be required to increase muscle mass as a result of intervention with a vitamin D and protein supplement in sarcopenic older adults. This suggests that current cut-offs in the recommendations for vitamin D and protein intake could be considered the "minimum" for adults with sarcopenia to respond adequately to nutrition strategies aimed at attenuating muscle loss. (C) 2017 The Author(s). Published by Elsevier Ltd.


FAU Authors / FAU Editors

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)


External institutions with authors

Bezoekadres NV Nutricia
Carl von Ossietzky Universität Oldenburg
CHU Clermont-Ferrand
Newcastle University
Università degli studi "La Sapienza"
University of Dundee
University of Parma / Università degli Studi di Parma
Uppsala University Hospital / Akademiska sjukhuset
Vrije Universiteit Amsterdam (VU) / University Amsterdam
Vrije Universiteit Brussel


How to cite

APA:
Verlaan, S., Maier, A.B., Bauer, J.M., Bautmans, I., Brandt, K., Donini, L.M.,... Cederholm, T. (2018). Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study. Clinical Nutrition, 37(2), 551-557. https://dx.doi.org/10.1016/j.clnu.2017.01.005

MLA:
Verlaan, Sjors, et al. "Sufficient levels of 25-hydroxyvitamin D and protein intake required to increase muscle mass in sarcopenic older adults - The PROVIDE study." Clinical Nutrition 37.2 (2018): 551-557.

BibTeX: 

Last updated on 2018-13-08 at 10:38