Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications

Idris MIB, Zaloga J, Detsch R, Roether J, Unterweger H, Alexiou C, Boccaccini AR (2018)

Publication Language: English

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2018

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Publisher: Nature Publishing Group

Book Volume: 8

Article Number: 7286

Journal Issue: 1

DOI: 10.1038/s41598-018-25243-9

Abstract

Surface modification of superparamagnetic iron oxide nanoparticles (SPIONs) has been introduced with lauric acid and oleic acid via co-precipitation and thermal decomposition methods, respectively. This modification is required to increase the stability of SPIONs when incorporated in hydrophobic, biodegradable and biocompatible polymers such as poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this work, the solid-in-oil-in-water (S/O/W) emulsion-solvent extraction/evaporation method was utilized to fabricate magnetic polymer microspheres incorporating SPIONs in PHBV. The prepared magnetic PHBV microspheres exhibited particle sizes <1 mu m. The presence of functional groups of lauric acid, oleic acid and iron oxide in the PHBV microspheres was confirmed by Fourier Transform Infrared spectroscopy (FTIR). X-ray diffraction (XRD) analysis was performed to further confirm the success of the combination of modified SPIONs and PHBV. Thermogravimetric analysis (TGA) indicated that PHBV microspheres were incorporated with SPIONs(Lauric) as compared with SPIONs(Oleic). This was also proven via magnetic susceptibility measurement as a higher value of this magnetic property was detected for PHBV/SPIONs(Lauric) microspheres. It was revealed that the magnetic PHBV microspheres were non-toxic when assessed with mouse embryotic fibroblast cells (MEF) at different concentrations of microspheres. These results confirmed that the fabricated magnetic PHBV microspheres are potential candidates for use in biomedical applications.

Authors with CRIS profile

Maizlinda Izwana Binti Idris Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Jan Zaloga Department of Otorhinolaryngology – Head and Neck Surgery Rainer Detsch Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Judith Roether Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe) Harald Unterweger Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

How to cite

APA:

Idris, M.I.B., Zaloga, J., Detsch, R., Roether, J., Unterweger, H., Alexiou, C., & Boccaccini, A.R. (2018). Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications. Scientific Reports, 8(1). https://dx.doi.org/10.1038/s41598-018-25243-9

MLA:

Idris, Maizlinda Izwana Binti, et al. "Surface Modification of SPIONs in PHBV Microspheres for Biomedical Applications." Scientific Reports 8.1 (2018).

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