Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications

Journal article


Publication Details

Author(s): Nawaz Q, Ur Rehman MA, Burkovski A, Schmidt J, Beltran AM, Shahid A, Alber NK, Peukert W, Boccaccini AR
Journal: Journal of Materials Science-Materials in Medicine
Publisher: SPRINGER
Publication year: 2018
Volume: 29
Journal issue: 5
ISSN: 0957-4530


Abstract

Mesoporous bioactive glass (BG) nanoparticles based in the system: SiO2-P2O5-CaO-MnO were synthesized via a modified Stober process at various concentrations of Mn (0-7 mol %). The synthesized manganese-doped BG nanoparticles were characterized in terms of morphology, composition, in vitro bioactivity and antibacterial activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis confirmed that the particles had spherical morphology (mean particle size: 110 nm) with disordered mesoporous structure. Energy dispersive X-ray spectroscopy (EDX) confirmed the presence of Mn, Ca, Si and P in the synthesized Mn-doped BG particles. Moreover, X-ray diffraction (XRD) analysis showed that Mn has been incorporated in the amorphous silica network (bioactive glass). Moreover, it was found that manganese-doped BG particles form apatite crystals upon immersion in simulated body fluid (SBF). Inductively coupled plasma atomic emission spectroscopy (ICP-OES) measurements confirmed that Mn is released in a sustained manner, which provided antibacterial effect against Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. The results indicate that the incorporation of Mn in the bioactive glass network is an effective strategy to develop novel multifunctional BG nanoparticles for bone tissue engineering.


FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Burkovski, Andreas Prof. Dr.
Professur für Mikrobiologie
Nawaz, Qaisar
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Peukert, Wolfgang Prof. Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Schmidt, Jochen
Lehrstuhl für Anorganische und Metallorganische Chemie
Shahid, Ameen
Lehrstuhl für Chemische Reaktionstechnik
Ur Rehman, Muhammad Atiq
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

University of Seville / Universidad de Sevilla


How to cite

APA:
Nawaz, Q., Ur Rehman, M.A., Burkovski, A., Schmidt, J., Beltran, A.M., Shahid, A.,... Boccaccini, A.R. (2018). Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications. Journal of Materials Science-Materials in Medicine, 29(5). https://dx.doi.org/10.1007/s10856-018-6070-4

MLA:
Nawaz, Qaisar, et al. "Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications." Journal of Materials Science-Materials in Medicine 29.5 (2018).

BibTeX: 

Last updated on 2018-05-11 at 15:08