Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications

Nawaz Q, Ur Rehman MA, Burkovski A, Schmidt J, Beltran AM, Shahid A, Alber NK, Peukert W, Boccaccini AR (2018)


Publication Status: Published

Publication Type: Journal article

Publication year: 2018

Journal

Publisher: SPRINGER

Book Volume: 29

Journal Issue: 5

DOI: 10.1007/s10856-018-6070-4

Abstract

Mesoporous bioactive glass (BG) nanoparticles based in the system: SiO2-P2O5-CaO-MnO were synthesized via a modified Stober process at various concentrations of Mn (0-7 mol %). The synthesized manganese-doped BG nanoparticles were characterized in terms of morphology, composition, in vitro bioactivity and antibacterial activity. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis confirmed that the particles had spherical morphology (mean particle size: 110 nm) with disordered mesoporous structure. Energy dispersive X-ray spectroscopy (EDX) confirmed the presence of Mn, Ca, Si and P in the synthesized Mn-doped BG particles. Moreover, X-ray diffraction (XRD) analysis showed that Mn has been incorporated in the amorphous silica network (bioactive glass). Moreover, it was found that manganese-doped BG particles form apatite crystals upon immersion in simulated body fluid (SBF). Inductively coupled plasma atomic emission spectroscopy (ICP-OES) measurements confirmed that Mn is released in a sustained manner, which provided antibacterial effect against Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus. The results indicate that the incorporation of Mn in the bioactive glass network is an effective strategy to develop novel multifunctional BG nanoparticles for bone tissue engineering.

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APA:

Nawaz, Q., Ur Rehman, M.A., Burkovski, A., Schmidt, J., Beltran, A.M., Shahid, A.,... Boccaccini, A.R. (2018). Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications. Journal of Materials Science: Materials in Medicine, 29(5). https://doi.org/10.1007/s10856-018-6070-4

MLA:

Nawaz, Qaisar, et al. "Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications." Journal of Materials Science: Materials in Medicine 29.5 (2018).

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