Mdm2 SNP309 G-Variant Is Associated with Invasive Growth of Human Urinary Bladder Cancer

Hitzenbichler F, Stoehr CG, Rogenhofer M, Wieland WF, Ruemmele P, Hartmann A, Stoehr R (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Pathobiology Karger

Publisher: Karger

Book Volume: 81

Pages Range: 53-9

Journal Issue: 2

DOI: 10.1159/000355976

Abstract

Objective: Human mouse double minute 2 (Mdm2) is essential in degrading p53 by acting as an ubiquitin ligase and therefore plays a vital role in cell cycle and survival. The G-variant of the Mdm2 SNP309, which is located within the promoter of the Mdm2 gene, increases expression of Mdm2 and thereby inhibits the p53 pathway. Several studies have investigated the influence of this SNP on disease risk and onset of various malignancies. The impact of Mdm2 SNP309 on bladder cancer is still to be established due to inconsistent data. Methods: In a case-control study we determined the distribution of Mdm2 SNP309 genotypes in 111 patients with an early-onset bladder cancer (diagnosis <45 years of age), in 113 consecutive bladder cancer patients and in a control group consisting of 140 patients without any malignancy. Results: There was no significant association between the allelic distribution of the Mdm2 SNP309 and tumor risk, early onset, gender or grade of the tumor. According to tumor stage we found a significant difference in the distribution of the Mdm2 SNP309 between patients with noninvasive and invasive (>=pT1) tumor growth (p = 0.016). In patients with invasive tumors a significant increase of the G allele was found (T/T vs. T/G + G/G; p = 0.023; OR 2.203, 95% CI 1.111-4.369). Conclusion: These data indicate that the G-variant of the Mdm2 SNP309 might influence the development of a more aggressive tumor phenotype in patients with bladder cancer without affecting the overall tumor risk. © 2013 S. Karger AG, Basel.

Authors with CRIS profile

Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Universität Regensburg DE Germany (DE)

How to cite

APA:

Hitzenbichler, F., Stoehr, C.G., Rogenhofer, M., Wieland, W.F., Ruemmele, P., Hartmann, A., & Stoehr, R. (2014). Mdm2 SNP309 G-Variant Is Associated with Invasive Growth of Human Urinary Bladder Cancer. Pathobiology, 81(2), 53-9. https://dx.doi.org/10.1159/000355976

MLA:

Hitzenbichler, Florian, et al. "Mdm2 SNP309 G-Variant Is Associated with Invasive Growth of Human Urinary Bladder Cancer." Pathobiology 81.2 (2014): 53-9.

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