N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis

Journal article

Publication Details

Author(s): Allanore Y, Komocsi A, Vettori S, Hachulla E, Hunzelmann N, Distler J, Avouac J, Gobeaux C, Launay D, Czirjak L, Kahan A, Meune C
Journal: International Journal of Cardiology
Publication year: 2016
Volume: 223
Pages range: 385-389
ISSN: 0167-5273


Cardiovascular involvement is a major contributor to mortality in systemic sclerosis (SSc). We examined whether N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor of mortality in SSc.This multicentre prospective cohort study included 523 patients presenting with SSc, whose mean age was 54±13years, mean disease duration 8±9years, and diffuse cutaneous form in 168. Plasma NT-proBNP was measured at baseline and the patients were followed yearly. Overall mortality was measured at 3years. At baseline, cardiovascular involvement was present in 37 patients, including 17 with pulmonary artery hypertension (PAH) and 20 with a left ventricular ejection fraction (LVEF) <55%. At 3years, 32 (7%) patients had died. The median [25th-75th percentile] NT-proBNP concentration was 203ng/l [129-514] in patients who died within 3years, versus 88ng/l [47-167] in survivors (P<0.001). NT-proBNP was an independent predictor of 3-years mortality in multivariate analysis (P=0.046). The optimal cut-off derived from the ROC curve was 129ng/l; sensitivity and specificity to predict 3y mortality were 78.1 and 66.7%. Using the previously recommended 125-ng/l concentration as threshold value, NT-proBNP reliably and independently predicted 3year mortality, with a sensitivity of 78.1 and a negative predictive value of 97.6%, respectively (P=0.006). The consideration of SSc patients without PAH or LVEF<55% at baseline yielded similar results.NT-proBNP appears as a reliable and independent predictor of mortality in patients with SSc.

FAU Authors / FAU Editors

Distler, Jörg PD Dr.
Heisenberg-Professur für Molekulare Mechanismen der Organfibrose

External institutions
LILLE 1 University - Science and Technology
Seconda Universita degli Studi di Napoli (SUN)
Universität Köln
University of Paris 13 - Paris-Nord / Université Paris XIII Paris-Nord
University of Paris 5 - René Descartes / Université Paris V René Descartes
University of Pécs

How to cite

Allanore, Y., Komocsi, A., Vettori, S., Hachulla, E., Hunzelmann, N., Distler, J.,... Meune, C. (2016). N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis. International Journal of Cardiology, 223, 385-389. https://dx.doi.org/10.1016/j.ijcard.2016.08.246

Allanore, Yannick, et al. "N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis." International Journal of Cardiology 223 (2016): 385-389.


Last updated on 2018-10-10 at 11:23