Oncogenic roles of EMT-inducing transcription factors

Journal article


Publication Details

Author(s): Puisieux A, Brabletz T, Caramel J
Journal: Nature Cell Biology
Publisher: Nature Publishing Group
Publication year: 2014
Volume: 16
Journal issue: 6
Pages range: 488-94
ISSN: 1465-7392


Abstract


The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.



FAU Authors / FAU Editors

Brabletz, Thomas Prof. Dr. med.
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung


External institutions with authors

Centre Léon-Bérard (UNICANCER)


How to cite

APA:
Puisieux, A., Brabletz, T., & Caramel, J. (2014). Oncogenic roles of EMT-inducing transcription factors. Nature Cell Biology, 16(6), 488-94. https://dx.doi.org/10.1038/ncb2976

MLA:
Puisieux, Alain, Thomas Brabletz, and Julie Caramel. "Oncogenic roles of EMT-inducing transcription factors." Nature Cell Biology 16.6 (2014): 488-94.

BibTeX: 

Last updated on 2018-10-10 at 11:23

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