Oncogenic roles of EMT-inducing transcription factors

Puisieux A, Brabletz T, Caramel J (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Nature Cell Biology Nature Research

Publisher: Nature Publishing Group

Book Volume: 16

Pages Range: 488-94

Journal Issue: 6

DOI: 10.1038/ncb2976

Abstract

The plasticity of cancer cells underlies their capacity to adapt to the selective pressures they encounter during tumour development. Aberrant reactivation of epithelial-mesenchymal transition (EMT), an essential embryonic process, can promote cancer cell plasticity and fuel both tumour initiation and metastatic spread. Here we discuss the roles of EMT-inducing transcription factors in creating a pro-tumorigenic setting characterized by an intrinsic ability to withstand oncogenic insults through the mitigation of p53-dependent oncosuppressive functions and the gain of stemness-related properties.

Authors with CRIS profile

Thomas Brabletz Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung

Involved external institutions

Centre Léon-Bérard (UNICANCER) FR France (FR)

How to cite

APA:

Puisieux, A., Brabletz, T., & Caramel, J. (2014). Oncogenic roles of EMT-inducing transcription factors. Nature Cell Biology, 16(6), 488-94. https://dx.doi.org/10.1038/ncb2976

MLA:

Puisieux, Alain, Thomas Brabletz, and Julie Caramel. "Oncogenic roles of EMT-inducing transcription factors." Nature Cell Biology 16.6 (2014): 488-94.

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