Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis

Qvist T, Taylor-Robinson D, Waldmann E, Olesen HV, Hansen CR, Mathiesen IH, Hoiby N, Katzenstein TL, Smyth RL, Diggle PJ, Pressler T (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Journal of Cystic Fibrosis Elsevier

Book Volume: 15

Pages Range: 380-5

Journal Issue: 3

DOI: 10.1016/j.jcf.2015.09.007

Abstract

To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed the impact of each infection in a Danish setting.Longitudinal registry study of 432 patients with cystic fibrosis contributing 53,771 lung function measures between 1974 and 2014. We used a mixed effects model with longitudinally structured correlation, while adjusting for clinically important covariates.Infections with a significant impact on rate of decline in %FEV1 were Mycobacterium abscessus complex with -2.22% points per year (95% CI -3.21 to -1.23), Burkholderia cepacia complex -1.95% (95% CI -2.51 to -1.39), Achromobacterxylosoxidans -1.55% (95% CI -2.21 to -0.90), and Pseudomonas aeruginosa -0.95% (95% CI -1.24 to -0.66). Clearing M. abscessus complex was associated with a change to a slower decline, similar in magnitude to the pre-infection slope.In a national population we have demonstrated the impact on lung function of each chronic CF pathogen. M. abscessus complex was associated with the worst impact on lung function. Eradication of M. abscessus complex may significantly improve lung function.

Authors with CRIS profile

Elisabeth Bergherr Lehrstuhl für Biometrie und Epidemiologie

Involved external institutions

University of Copenhagen DK Denmark (DK) Lancaster University GB United Kingdom (GB) University College London (UCL) GB United Kingdom (GB) Aarhus University Hospital / Aarhus Universitetshospital DK Denmark (DK) The University of Liverpool GB United Kingdom (GB)

How to cite

APA:

Qvist, T., Taylor-Robinson, D., Waldmann, E., Olesen, H.V., Hansen, C.R., Mathiesen, I.H.,... Pressler, T. (2016). Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis. Journal of Cystic Fibrosis, 15(3), 380-5. https://dx.doi.org/10.1016/j.jcf.2015.09.007

MLA:

Qvist, Tavs, et al. "Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis." Journal of Cystic Fibrosis 15.3 (2016): 380-5.

BibTeX: Download