Signaling pathways and tissue interactions in neural plate border formation

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Schille C, Schambony A
Zeitschrift: Neurogenesis
Jahr der Veröffentlichung: 2017
Band: 4
Heftnummer: 1
Seitenbereich: e1292783
ISSN: 2326-2133
Sprache: Englisch


The neural crest is a transient cell population that gives rise to various cell types of multiple tissues and organs in the vertebrate embryo. Neural crest cells arise from the neural plate border, a region localized at the lateral borders of the prospective neural plate. Temporally and spatially coordinated interaction with the adjacent tissues, the non-neural ectoderm, the neural plate and the prospective dorsolateral mesoderm, is required for neural plate border specification. Signaling molecules, namely BMP, Wnt and FGF ligands and corresponding antagonists are derived from these tissues and interact to induce the expression of neural plate border specific genes. The present mini-review focuses on the current understanding of how the NPB territory is formed and accentuates the need for coordinated interaction of BMP and Wnt signaling pathways and precise tissue communication that are required for the definition of the prospective NC in the competent ectoderm.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Schambony, Alexandra Prof. Dr.
Lehrstuhl für Entwicklungsbiologie
Schille, Carolin
Lehrstuhl für Entwicklungsbiologie


Schille, C., & Schambony, A. (2017). Signaling pathways and tissue interactions in neural plate border formation. Neurogenesis, 4(1), e1292783.

Schille, Carolin, and Alexandra Schambony. "Signaling pathways and tissue interactions in neural plate border formation." Neurogenesis 4.1 (2017): e1292783.


Zuletzt aktualisiert 2018-18-10 um 04:00