Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Klein S, Sommer A, Distel L, Hazemann JL, Kroener W, Neuhuber W, Müller P, Proux O, Kryschi C
Zeitschrift: Journal of Physical Chemistry B
Verlag: American Chemical Society
Jahr der Veröffentlichung: 2014
Band: 118
Heftnummer: 23
Seitenbereich: 6159-6166
ISSN: 1520-6106
eISSN: 1520-5207


Abstract


Superparamagnetic iron oxide nanoparticles (SPIONs) with a mixed phase composition (γ-FeO)(Fe O)and sizes between 9 and 20 nm were synthesized via coprecipitation and were either left uncoated or subsequently surface-stabilized with citrate or malate anions. The sizes, morphology, surface chemistry, and magnetic properties of the nanoparticles were characterized using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy, and superconducting quantum interference device measurements, respectively. Cellular uptake and intracellular distribution in normal tissue and tumor cells were verified by TEM images. X-ray-induced changes of the oxidation state and site geometries of surface iron ions of uncoated and citrate-coated SPIONs were explored by collecting Fe K-edge X-ray absorption spectroscopy data. The potential applicability of citrate- and malate-coated SPIONs as an X-ray enhancer for radiation cancer therapy was substantiated by their drastic enhancement of the concentration of reactive oxygen species (ROS) in X-ray irradiated tumor cells. © 2014 American Chemical Society.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Distel, Luitpold Prof. Dr.
Strahlenklinik
Klein, Stefanie Dr.
Lehrstuhl für Physikalische Chemie I
Kroener, Wolfgang
Lehrstuhl für Experimentalphysik
Kryschi, Carola Prof. Dr.
Professur für Physikalische Chemie
Müller, Paul Prof. Dr.
Naturwissenschaftliche Fakultät
Neuhuber, Winfried Prof. Dr.
Lehrstuhl für Anatomie und Zellbiologie
Sommer, Anja
Lehrstuhl für Physikalische Chemie I


Einrichtungen weiterer Autorinnen und Autoren

Université Joseph Fourier (UJF Grenoble 1)


Zitierweisen

APA:
Klein, S., Sommer, A., Distel, L., Hazemann, J.-L., Kroener, W., Neuhuber, W.,... Kryschi, C. (2014). Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy. Journal of Physical Chemistry B, 118(23), 6159-6166. https://dx.doi.org/10.1021/jp5026224

MLA:
Klein, Stefanie, et al. "Superparamagnetic iron oxide nanoparticles as novel x-ray enhancer for low-dose radiation therapy." Journal of Physical Chemistry B 118.23 (2014): 6159-6166.

BibTeX: 

Zuletzt aktualisiert 2019-06-04 um 21:50