Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Söder S, Sesselmann S, Aigner T, Oehler S, Agaimy A
Zeitschrift: Virchows Archiv
Jahr der Veröffentlichung: 2016
Band: 468
Heftnummer: 2
Seitenbereich: 231-8
ISSN: 0945-6317


Tenosynovial giant cell tumour (TSGCT; synonym, pigmented villonodular synovitis (PVNS)) is a rare low-grade mesenchymal neoplasm of either intra-articular or extra-articular origin. The etiopathogenesis of TSGCT is still uncertain, but recent studies showed a translocation involving colony-stimulating factor 1 (CSF-1) gene in a subset of cases. Histological features mimicking TSGCT can sometimes be encountered in periprosthetic interface membranes. To investigate the frequency and morphologic spectrum of this phenomenon, we conducted a systematic analysis of 477 periprosthetic interface membranes and performed immunohistochemical analysis on a subset of lesions compared to genuine TSGCT. In 26 of 477 periprosthetic membrane samples (5 %), at least some TSGCT-like features were found and 18 cases (4 %) strongly resembled it. Wear particles were detected in 100 % of the TSGCT-like lesions but only in 63.3 % of the whole cohort of periprosthetic membranes (p value <0.001). Immunohistochemistry comparing true TSGCT and TSGCT-like membranes showed similar inflammatory infiltrates with slightly elevated CD3+/CD8+ T lymphocytes and a slightly higher proliferation index in TSGCT samples. In conclusion, TSGCT-like changes in periprosthetic membranes likely represent exuberant fibrohistiocytic inflammatory response induced by wear particles and should be distinguished from genuine (neoplastic) TSGCT. Although TSGCT and TSGCT-like periprosthetic membranes represent different entities, their comparable morphology might reflect analogous morphogenesis.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie
Sesselmann, Stefan Dr.
Lehrstuhl für Orthopädie mit Orthopädischer Chirurgie

Einrichtungen weiterer Autorinnen und Autoren

Klinikum Coburg
Krankenhaus Rummelsberg


Söder, S., Sesselmann, S., Aigner, T., Oehler, S., & Agaimy, A. (2016). Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. Virchows Archiv, 468(2), 231-8. https://dx.doi.org/10.1007/s00428-015-1874-9

Söder, Stephan, et al. "Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes." Virchows Archiv 468.2 (2016): 231-8.


Zuletzt aktualisiert 2018-14-11 um 06:08