Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes

Söder S, Sesselmann S, Aigner T, Oehler S, Agaimy A (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Virchows Archiv Springer Verlag (Germany)

Book Volume: 468

Pages Range: 231-8

Journal Issue: 2

DOI: 10.1007/s00428-015-1874-9

Abstract

Tenosynovial giant cell tumour (TSGCT; synonym, pigmented villonodular synovitis (PVNS)) is a rare low-grade mesenchymal neoplasm of either intra-articular or extra-articular origin. The etiopathogenesis of TSGCT is still uncertain, but recent studies showed a translocation involving colony-stimulating factor 1 (CSF-1) gene in a subset of cases. Histological features mimicking TSGCT can sometimes be encountered in periprosthetic interface membranes. To investigate the frequency and morphologic spectrum of this phenomenon, we conducted a systematic analysis of 477 periprosthetic interface membranes and performed immunohistochemical analysis on a subset of lesions compared to genuine TSGCT. In 26 of 477 periprosthetic membrane samples (5 %), at least some TSGCT-like features were found and 18 cases (4 %) strongly resembled it. Wear particles were detected in 100 % of the TSGCT-like lesions but only in 63.3 % of the whole cohort of periprosthetic membranes (p value <0.001). Immunohistochemistry comparing true TSGCT and TSGCT-like membranes showed similar inflammatory infiltrates with slightly elevated CD3+/CD8+ T lymphocytes and a slightly higher proliferation index in TSGCT samples. In conclusion, TSGCT-like changes in periprosthetic membranes likely represent exuberant fibrohistiocytic inflammatory response induced by wear particles and should be distinguished from genuine (neoplastic) TSGCT. Although TSGCT and TSGCT-like periprosthetic membranes represent different entities, their comparable morphology might reflect analogous morphogenesis.

Authors with CRIS profile

Stefan Sesselmann Departement of Orthopaedic Surgery Abbas Agaimy Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie

Involved external institutions

Klinikum Coburg DE Germany (DE) Krankenhaus Rummelsberg DE Germany (DE)

How to cite

APA:

Söder, S., Sesselmann, S., Aigner, T., Oehler, S., & Agaimy, A. (2016). Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes. Virchows Archiv, 468(2), 231-8. https://dx.doi.org/10.1007/s00428-015-1874-9

MLA:

Söder, Stephan, et al. "Tenosynovial giant cell tumour (pigmented villonodular synovitis-)-like changes in periprosthetic interface membranes." Virchows Archiv 468.2 (2016): 231-8.

BibTeX: Download