New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation

Journal article


Publication Details

Author(s): Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
Journal: Frontiers in Immunology
Publication year: 2016
Volume: 7
Pages range: 302
ISSN: 1664-3224


Abstract


Recent data suggest that NETosis plays a crucial role in the innate immune response and disturbs the homeostasis of the immune system. NETosis is a form of neutrophil-specific cell death characterized by the release of large web-like structures referred to as neutrophil extracellular traps (NETs). NETs are composed of DNA strands associated with histones and decorated with about 20 different proteins, including neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, high mobility group protein B1, and LL37. Reportedly, NETosis can be induced by several microbes, and particulate matter including sterile stimuli, via distinct cellular mechanisms. Meanwhile, suicidal NETosis and vital NETosis are controversial. As we enter the second decade of research on NETosis, we have partly understood NETs as double-edged swords of innate immunity. In this review, we will discuss the mechanisms of NETosis, its antimicrobial action, and role in autoimmune diseases, as well as the relatively new field of NET-associated mitochondrial DNA.



FAU Authors / FAU Editors

Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions with authors

Sichuan University (SCU) / 四川大学


How to cite

APA:
Yang, H., Biermann, M.H., Brauner, J.M., Liu, Y., Zhao, Y., & Herrmann, M. (2016). New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation. Frontiers in Immunology, 7, 302. https://dx.doi.org/10.3389/fimmu.2016.00302

MLA:
Yang, Hang, et al. "New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation." Frontiers in Immunology 7 (2016): 302.

BibTeX: 

Last updated on 2019-17-04 at 08:17