New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel F, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Proemel S, Ressl S, Schioth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X (2014)

Publication Type: Journal article

Publication year: 2014

Journal

Book Volume: 1333

Pages Range: 43-64

Journal Issue: 1

DOI: 10.1111/nyas.12580

Abstract

The class of adhesion G protein-coupled receptors (aGPCRs), with 33 human homologs, is the second largest family of GPCRs. In addition to a seven-transmembrane ?-helix-a structural feature of all GPCRs-the class of aGPCRs is characterized by the presence of a large N-terminal extracellular region. In addition, all aGPCRs but one (GPR123) contain a GPCR autoproteolysis-inducing (GAIN) domain that mediates autoproteolytic cleavage at the GPCR autoproteolysis site motif to generate N- and a C-terminal fragments (NTF and CTF, respectively) during protein maturation. Subsequently, the NTF and CTF are associated noncovalently as a heterodimer at the plasma membrane. While the biological function of the GAIN domain-mediated autocleavage is not fully understood, mounting evidence suggests that the NTF and CTF possess distinct biological activities in addition to their function as a receptor unit. We discuss recent advances in understanding the biological functions, signaling mechanisms, and disease associations of the aGPCRs.

Authors with CRIS profile

Involved external institutions

Universität Leipzig Germany (DE) University of Kansas (KU) United States (USA) (US) University of Chicago United States (USA) (US) Tokyo Institute of Technology Japan (JP) Boston Children's Hospital United States (USA) (US) Massachusetts Institute of Technology (MIT) United States (USA) (US) Cincinnati Children's Hospital Medical Center United States (USA) (US) Houston Texas Medical Center United States (USA) (US) Harvard University United States (USA) (US) Université Catholique de Louvain (UCL) Belgium (BE) Emory University United States (USA) (US) University of Amsterdam Netherlands (NL) Julius-Maximilians-Universität Würzburg Germany (DE) Chang Gung University (CGU) / 長庚大學 Taiwan (TW) East China Normal University (ECNU) / 华东师范大学 China (CN) Washington University United States (USA) (US) University of Copenhagen Denmark (DK) Stanford University United States (USA) (US) Uppsala University Sweden (SE) Collège de France France (FR) Massachusetts Eye and Ear (MEE) United States (USA) (US) University of Rochester (UR) United States (USA) (US) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE)

How to cite

APA:

Liebscher, I., Ackley, B., Arac, D., Ariestanti, D.M., Aust, G., Bae, B.-I.,... Piao, X. (2014). New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences, 1333(1), 43-64. https://dx.doi.org/10.1111/nyas.12580

MLA:

Liebscher, Ines, et al. "New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors." Annals of the New York Academy of Sciences 1333.1 (2014): 43-64.

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