Gryc T, Ott O, Putz F, Knippen S, Raptis D, Fietkau R, Strnad V (2016)
Publication Type: Journal article
Publication year: 2016
Book Volume: 15
Pages Range: 865-872
Journal Issue: 6
DOI: 10.1016/j.brachy.2016.08.003
To analyze the efficacy of a protocol-based brachytherapy (BT) boost after external beam radiation therapy (EBRT) with simultaneous chemotherapy in patients with anal carcinoma.About 190 patients have been analyzed. Around 143 patients were identified with a good clinical response at the end of EBRT. Another 47 patients received an additional BT boost to the residual tumor at 6 weeks after end of chemoradiation.The 5-year incidence of local recurrence was 24% in patients with BT boost and 19% in patients without BT boost (p = 0.238). The 5-year disease-free survival rate, overall survival rate, and colostomy-free survival rate were 64% and 75% and 76.1% in the BT group and 69% (p = 0.212), 72% (p = 0.924), and 82.7% (p = 0.488) in the non-BT group. We found no differences in late toxicity between the groups.For patients with anal cancer with not a good response to 50-59 Gy EBRT with simultaneous chemotherapy, the further dose escalation using the BT boost up to a mean of 67.5 Gy seems to improve the clinical outcome to the same level as observed in patients with a good response to ERBT, without an increase in late side effects.
APA:
Gryc, T., Ott, O., Putz, F., Knippen, S., Raptis, D., Fietkau, R., & Strnad, V. (2016). Interstitial brachytherapy as a boost to patients with anal carcinoma and poor response to chemoradiation: Single-institution long-term results. Brachytherapy, 15(6), 865-872. https://doi.org/10.1016/j.brachy.2016.08.003
MLA:
Gryc, Thomas, et al. "Interstitial brachytherapy as a boost to patients with anal carcinoma and poor response to chemoradiation: Single-institution long-term results." Brachytherapy 15.6 (2016): 865-872.
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