Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells
Bonsmann MSG, Niezold T, Temchura V, Pissani F, Ehrhardt K, Brown EP, Osei-Owusu NY, Hannaman D, Hengel H, Ackerman ME, Streeck H, Nabi G, Tenbusch M, Ueberla K (2015)
Publication Type: Journal article
Publication year: 2015
Journal
Book Volume: 195
Pages Range: 4861-72
Journal Issue: 10
Abstract
The importance of Fc-dependent effector functions of Abs induced by vaccination is increasingly recognized. However, vaccination of mice against HIV envelope (Env) induced a skewed Th cell response leading to Env-specific Abs with reduced effector function. To overcome this bias, GagPol-specific Th cells were harnessed to provide intrastructural help for Env-specific B cells after immunization with virus-like particles containing GagPol and Env. This led to a balanced Env-specific humoral immune response with a more inflammatory Fc glycan profile. The increased quality in the Ab response against Env was confirmed by Fc?R activation assays. Because the Env-specific Th cell response was also biased in human vaccinees, intrastructural help is an attractive novel approach to increase the efficacy of prophylactic HIV Env-based vaccines and may also be applicable to other particulate vaccines.
Involved external institutions
Ruhr-Universität Bochum (RUB)
Germany (DE)
MHRP U.S. Military HIV Research Program
United States (USA) (US)
Dartmouth College
United States (USA) (US)
Universitätsklinikum Freiburg
Germany (DE)
Ichor Medical Systems, Inc.
United States (USA) (US)
Germany (DE)
MHRP U.S. Military HIV Research Program
United States (USA) (US)
Dartmouth College
United States (USA) (US)
Universitätsklinikum Freiburg
Germany (DE)
Ichor Medical Systems, Inc.
United States (USA) (US)
How to cite
APA:
Bonsmann, M.S.G., Niezold, T., Temchura, V., Pissani, F., Ehrhardt, K., Brown, E.P.,... Ueberla, K. (2015). Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells. Journal of Immunology, 195(10), 4861-72. https://dx.doi.org/10.4049/jimmunol.1501377
MLA:
Bonsmann, Michael Storcksdieck Genannt, et al. "Enhancing the Quality of Antibodies to HIV-1 Envelope by GagPol-Specific Th Cells." Journal of Immunology 195.10 (2015): 4861-72.
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