Acrylonitrile exposure in the general population following a major train accident in Belgium: A human biomonitoring study

Journal article


Publication Details

Author(s): De Smedt T, De Cremer K, Vleminckx C, Fierens S, Mertens B, Van Overmeire I, Bader M, De Paepe P, Göen T, Nemery B, Schettgen T, Stove C, Van Oyen H, Van Loco J, Van Nieuwenhuyse A
Journal: Toxicology Letters
Publication year: 2014
Volume: 231
Journal issue: 3
Pages range: 344-51
ISSN: 0378-4274


Abstract

On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN).To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure.Between May 18-25, 242 residents participated in the study. N-2-cyanoethylvaline (CEV), a biomarker that is highly specific for ACN exposure, was measured in the blood. To account for potential influence by smoking, cotinine was determined in the urine. Participants also filled in a short questionnaire.In the evacuated zone, 37.3% of the non-smokers and 40.0% of the smokers had CEV concentrations above the reference values of 10 and 200pmol/g globin, respectively, at the time of the train accident. Spatial mapping of the CEV concentrations depending on the residential address showed a distribution pattern following the sewage system.The train derailment resulted in a highly atypical sequence-of-events. In addition to exposure in the direct vicinity of the site of the train derailment, exposure also occurred via the sewage system, into which acrylonitrile had entered shortly after the accident.


FAU Authors / FAU Editors

Göen, Thomas Prof. Dr.
Medizinische Fakultät


External institutions with authors

BASF SE
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen
Scientific Institute of Public Health
Universiteit Gent (UGent) / Ghent University
University Hospital Ghent


How to cite

APA:
De Smedt, T., De Cremer, K., Vleminckx, C., Fierens, S., Mertens, B., Van Overmeire, I.,... Van Nieuwenhuyse, A. (2014). Acrylonitrile exposure in the general population following a major train accident in Belgium: A human biomonitoring study. Toxicology Letters, 231(3), 344-51. https://dx.doi.org/10.1016/j.toxlet.2014.09.009

MLA:
De Smedt, T., et al. "Acrylonitrile exposure in the general population following a major train accident in Belgium: A human biomonitoring study." Toxicology Letters 231.3 (2014): 344-51.

BibTeX: 

Last updated on 2018-10-10 at 08:25