Crowding of receptors induces ring-like adhesions in model membranes

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Schmidt D, Bihr T, Fenz S, Merkel R, Seifert U, Sengupta K, Smith AS
Zeitschrift: Biochimica Et Biophysica Acta-Molecular Cell Research
Verlag: ELSEVIER SCIENCE BV
Jahr der Veröffentlichung: 2015
Band: 1853
Heftnummer: 11
Seitenbereich: 2984-2991
ISSN: 0167-4889
Sprache: Englisch


Abstract


The dynamics of formation of macromolecular structures in adherent membranes is a key to a number of cellular processes. However, the interplay between protein reaction kinetics, diffusion and the morphology of the growing domains, governed by membrane mediated interactions, is still poorly understood. Here we show, experimentally and in simulations, that a rich phase diagram emerges from the competition between binding, cooperativity, molecular crowding and membrane spreading. In the cellular context, the spontaneously-occurring organization of adhesion domains in ring-like morphologies is particularly interesting. These are stabilized by the crowding of bulky proteins, and the membrane-transmitted correlations between bonds. Depending on the density of the receptors, this phase may be circumvented, and instead, the adhesions may grow homogeneously in the contact zone between two membranes. If the development of adhesion occurs simultaneously with membrane spreading, much higher accumulation of binders can be achieved depending on the velocity of spreading. The mechanisms identified here, in the context of our mimetic model, may shed light on the structuring of adhesions in the contact zones between two living cells. This article is part of a Special Issue entitled: Mechanobiology. (C) 2015 Elsevier B.V. All rights reserved.



FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Bihr, Timo
Professur für Theoretische Physik
Schmidt, Daniel
Professur für Theoretische Physik
Smith, Ana-Suncana Prof. Dr.
Professur für Theoretische Physik


Zusätzliche Organisationseinheit(en)
Exzellenz-Cluster Engineering of Advanced Materials


Einrichtungen weiterer Autorinnen und Autoren

Aix-Marseille University / Aix-Marseille Université
Forschungszentrum Jülich GmbH (FZJ)
Universität Stuttgart


Forschungsbereiche

A3 Multiscale Modeling and Simulation
Exzellenz-Cluster Engineering of Advanced Materials


Zitierweisen

APA:
Schmidt, D., Bihr, T., Fenz, S., Merkel, R., Seifert, U., Sengupta, K., & Smith, A.-S. (2015). Crowding of receptors induces ring-like adhesions in model membranes. Biochimica Et Biophysica Acta-Molecular Cell Research, 1853(11), 2984-2991. https://dx.doi.org/10.1016/j.bbamcr.2015.05.025

MLA:
Schmidt, Daniel, et al. "Crowding of receptors induces ring-like adhesions in model membranes." Biochimica Et Biophysica Acta-Molecular Cell Research 1853.11 (2015): 2984-2991.

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Zuletzt aktualisiert 2018-08-08 um 16:53

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