Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide
Maueröder C, Schall N, Meyer F, Mahajan A, Garnier B, Hahn J, Kienhoefer D, Hoffmann M, Muller S (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Pages Range: 16
Abstract
During inflammatory reaction, neutrophils exhibit numerous cellular and immunological functions, notably the formation of neutrophil extracellular traps (NETs) and autophagy. NETs are composed of decondensed chromatin fibers coated with various antimicrobial molecules derived from neutrophil granules. NETs participate in antimicrobial defense and can also display detrimental roles and notably trigger some of the immune features of systemic lupus erythematosus (SLE) and other autoimmune diseases. Autophagy is a complex and finely regulated mechanism involved in the cell survival/death balance that may be connected to NET formation. To shed some light on the connection between autophagy and NET formation, we designed a number of experiments in human neutrophils and both in normal and lupus-prone MRL/lpr mice to determine whether the synthetic peptide P140, which is capable of selectively modulating chaperone-mediated autophagy (CMA) in lymphocytes, could alter NET formation. P140/Lupuzor(TM) is currently being evaluated in phase III clinical trials involving SLE patients. Overall our in vitro and in vivo studies established that P140 does not influence NET formation, cytokine/chemokine production, or CMA in neutrophils. Thus, the beneficial effect of P140/Lupuzor(TM) in SLE is apparently not directly related to modulation of neutrophil function.
Authors with CRIS profile
Christian Maueröder
Department of Medicine 3 – Rheumatology and Immunology
Aparna Mahajan
Department of Medicine 3 – Rheumatology and Immunology
Jonas Hahn
Department of Medicine 3 – Rheumatology and Immunology
Markus Hoffmann
Department of Medicine 3 – Rheumatology and Immunology
Involved external institutions
France (FR)How to cite
APA:
Maueröder, C., Schall, N., Meyer, F., Mahajan, A., Garnier, B., Hahn, J.,... Muller, S. (2017). Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide. Frontiers in Immunology, 8, 16. https://dx.doi.org/10.3389/fimmu.2017.00016
MLA:
Maueröder, Christian, et al. "Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide." Frontiers in Immunology 8 (2017): 16.
BibTeX: Download