Inhibitory glycine receptors: an update

Dutertre S, Becker CM, Betz H (2012)

Publication Type: Journal article

Publication year: 2012

Journal

Journal of Biological Chemistry American Society for Biochemistry and Molecular Biology

Publisher: American Society for Biochemistry and Molecular Biology

Book Volume: 287

Pages Range: 40216-23

Journal Issue: 48

DOI: 10.1074/jbc.R112.408229

Abstract

Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR isoforms. GlyRs not only regulate the excitability of motor and afferent sensory neurons, including pain fibers, but also are involved in the processing of visual and auditory signals. Hence, GlyRs constitute promising targets for the development of therapeutically useful compounds.

Authors with CRIS profile

Cord-Michael Becker Institut für Biochemie

Involved external institutions

University of Queensland AU Australia (AU) Max-Planck-Institut für medizinische Forschung / Max Planck Institute for Medical Research DE Germany (DE)

How to cite

APA:

Dutertre, S., Becker, C.-M., & Betz, H. (2012). Inhibitory glycine receptors: an update. Journal of Biological Chemistry, 287(48), 40216-23. https://dx.doi.org/10.1074/jbc.R112.408229

MLA:

Dutertre, Sebastien, Cord-Michael Becker, and Heinrich Betz. "Inhibitory glycine receptors: an update." Journal of Biological Chemistry 287.48 (2012): 40216-23.

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