Drug release from collagen matrices including an evolving microstructure

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autor(en): Ray N, van Noorden T, Radu AF, Friess W, Knabner P
Zeitschrift: ZAMM - Zeitschrift für angewandte Mathematik und Mechanik
Verlag: Wiley-VCH Verlag
Jahr der Veröffentlichung: 2013
Band: 93
Seitenbereich: 811-822
ISSN: 0044-2267


Abstract


Biodegradable collagen matrices have become a promising alternative to traditional drug delivery systems. The relevant mechanisms in controlled drug release are the diffusion of water into the collagen matrix, the swelling of the matrix coming along with drug release, and enzymatic degradation of the matrix with additional simultaneous drug release. These phenomena have been extensively studied in the past experimentally, via numerical simulations as well as analytically. However, a rigorous derivation of the macroscopic model description, which includes the evolving microstructure due to the degradation process, is still lacking. Since matrix degradation leads to the release of physically entrapped active agent, a good understanding of these phenomena is very important. We present such a derivation using formal twoscale asymptotic expansion in a level set framework and complete our results with numerical simulations in comparison with experimental data. Biodegradable collagen matrices have become a~promising alternative to traditional drug delivery systems. The relevant mechanisms in controlled drug release are the diffusion of water into the collagen matrix, the swelling of the matrix coming along with drug release, and enzymatic degradation of the matrix with additional simultaneous drug release. These phenomena have been extensively studied in the past experimentally, via numerical simulations as well as analytically. However, a rigorous derivation of the macroscopic model description, which includes the evolving microstructure due to the degradation process, is still lacking. Since matrix degradation leads to the release of physically entrapped active agent, a~good understanding of these phenomena is very important. The authors present such a~derivation using formal twoscale asymptotic expansion in a~level set framework and complete their results with numerical simulations in comparison with experimental data. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.



FAU-Autoren / FAU-Herausgeber

Knabner, Peter Prof. Dr.
Lehrstuhl für Angewandte Mathematik
Ray, Nadja Dr.
Lehrstuhl für Angewandte Mathematik
van Noorden, Tycho Dr.
Lehrstuhl für Angewandte Mathematik


Autor(en) der externen Einrichtung(en)
University of Bergen


Zitierweisen

APA:
Ray, N., van Noorden, T., Radu, A.F., Friess, W., & Knabner, P. (2013). Drug release from collagen matrices including an evolving microstructure. ZAMM - Zeitschrift für angewandte Mathematik und Mechanik, 93, 811-822. https://dx.doi.org/10.1002/zamm.201200196

MLA:
Ray, Nadja, et al. "Drug release from collagen matrices including an evolving microstructure." ZAMM - Zeitschrift für angewandte Mathematik und Mechanik 93 (2013): 811-822.

BibTeX: 

Zuletzt aktualisiert 2018-05-12 um 20:50