Dimidschstein J, Passante L, Dufour A, Van Den Ameele J, Tiberi L, Hrechdakian T, Adams R, Klein R, Lie DC, Jossin Y, Vanderhaeghen P (2013)
Publication Type: Journal article
Publication year: 2013
Publisher: Elsevier (Cell Press)
Book Volume: 79
Pages Range: 1123-35
Journal Issue: 6
DOI: 10.1016/j.neuron.2013.07.015
Neurons of the cerebral cortex are organized in layers and columns. Unlike laminar patterning, the mechanisms underlying columnar organization remain largely unexplored. Here, we show that ephrin-B1 plays a key role in this process through the control of nonradial steps of migration of pyramidal neurons. In vivo gain of function of ephrin-B1 resulted in a reduction of tangential motility of pyramidal neurons, leading to abnormal neuronal clustering. Conversely, following genetic disruption of ephrin-B1, cortical neurons displayed a wider lateral dispersion, resulting in enlarged ontogenic columns. Dynamic analyses revealed that ephrin-B1 controls the lateral spread of pyramidal neurons by limiting neurite extension and tangential migration during the multipolar phase. Furthermore, we identified P-Rex1, a guanine-exchange factor for Rac3, as a downstream ephrin-B1 effector required to control migration during the multipolar phase. Our results demonstrate that ephrin-B1 inhibits nonradial migration of pyramidal neurons, thereby controlling the pattern of cortical columns.
APA:
Dimidschstein, J., Passante, L., Dufour, A., Van Den Ameele, J., Tiberi, L., Hrechdakian, T.,... Vanderhaeghen, P. (2013). Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration. Neuron, 79(6), 1123-35. https://doi.org/10.1016/j.neuron.2013.07.015
MLA:
Dimidschstein, Jordane, et al. "Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration." Neuron 79.6 (2013): 1123-35.
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