Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function

Journal article
(Original article)


Publication Details

Author(s): Li W, Ding Y, Rai R, Roether J, Schubert DW, Boccaccini AR
Journal: Materials Science and Engineering: C
Publisher: Elsevier
Publication year: 2014
Volume: 41
Pages range: 320-328
ISSN: 0928-4931
eISSN: 1873-0191


Abstract


PHBV microsphere/45S5 bioactive glass (BG) composite scaffolds with drug release function were developed for bone tissue engineering. BG-based glass-ceramic scaffolds with high porosity (94%) and interconnected pore structure prepared by foam replication method were coated with PHBV microspheres (nominal diameter = 3.5 μm) produced by water-in-oil-in-water double emulsion solvent evaporation method. A homogeneous microsphere coating throughout the porous structure of scaffolds was obtained by a simple dip coating method, using the slurry of PHBV microspheres in hexane. Compressive strength tests showed that the microsphere coating slightly improved the mechanical properties of the scaffolds. It was confirmed that the microsphere coating did not inhibit the bioactivity of the scaffolds in SBF. Hydroxyapatite crystals homogeneously grew not only on the struts of the scaffolds but also on the surface of microspheres within 7 days of immersion in SBF. Vancomycin was successfully encapsulated into the PHBV microspheres. The encapsulated vancomycin was released with a dual release profile involving a relatively low initial burst release (21%) and a sustained release (1 month), which is favorable compared to the high initial burst release (77%) and short release period (4 days) measured on uncoated scaffolds. The developed bioactive composite scaffold with drug delivery function has thus the potential to be used advantageously in bone tissue engineering. © 2014 Elsevier B.V. All rights reserved.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Ding, Yaping
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Li, Wei
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Rai, Ranjana
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)
Schubert, Dirk W. Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)


How to cite

APA:
Li, W., Ding, Y., Rai, R., Roether, J., Schubert, D.W., & Boccaccini, A.R. (2014). Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function. Materials Science and Engineering: C, 41, 320-328. https://dx.doi.org/10.1016/j.msec.2014.04.052

MLA:
Li, Wei, et al. "Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function." Materials Science and Engineering: C 41 (2014): 320-328.

BibTeX: 

Last updated on 2019-27-05 at 15:38