Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds

Journal article
(Original article)


Publication Details

Author(s): Cattalini JP, Hoppe A, Pishbin F, Roether J, Boccaccini AR, Lucangioli S, Mourino V
Journal: Journal of the Royal Society Interface
Publication year: 2015
Volume: 12
Journal issue: 110
ISSN: 1742-5662


Abstract


This work aimed to develop novel composite biomaterials for bone tissue engineering (BTE) made of bioactive glass nanoparticles (Nbg) and alginate cross-linked with Cu2+ or Ca2+ (AlgNbgCu, AlgNbgCa, respectively). Twodimensional scaffolds were prepared and the nanocomposite biomaterials were characterized in terms of morphology, mechanical strength, bioactivity, biodegradability, swelling capacity, release profile of the cross-linking cations and angiogenic properties. It was found that both Cu2+ and Ca2+ are released in a controlled and sustained manner with no burst release observed. Finally, in vitro results indicated that the bioactive ions released from both nanocomposite biomaterials were able to stimulate the differentiation of rat bone marrow-derived mesenchymal stem cells towards the osteogenic lineage. In addition, the typical endothelial cell property of forming tubes in Matrigel was observed for human umbilical vein endothelial cells when in contact with the novel biomaterials, particularly AlgNbgCu, which indicates their angiogenic properties. Hence, novel nanocomposite biomaterials made of Nbg and alginate cross-linked with Cu2+ or Ca2+ were developed with potential applications for preparation of multifunctional scaffolds for BTE.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Hoppe, Alexander
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Roether, Judith
Lehrstuhl für Werkstoffwissenschaften (Polymerwerkstoffe)


External institutions with authors

Imperial College London / The Imperial College of Science, Technology and Medicine
Universidad de Buenos Aires (UBA) / University of Buenos Aires


How to cite

APA:
Cattalini, J.P., Hoppe, A., Pishbin, F., Roether, J., Boccaccini, A.R., Lucangioli, S., & Mourino, V. (2015). Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds. Journal of the Royal Society Interface, 12(110). https://dx.doi.org/10.1098/rsif.2015.0509

MLA:
Cattalini, J. P., et al. "Novel nanocomposite biomaterials with controlled copper/calcium release capability for bone tissue engineering multifunctional scaffolds." Journal of the Royal Society Interface 12.110 (2015).

BibTeX: 

Last updated on 2019-22-08 at 21:50