AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Brechet A, Buchert R, Schwenk J, Boudkkazi S, Zolles G, Siquier-Pernet K, Schaber I, Bildl W, Saadi A, Bole-Feysot C, Nitschke P, Reis A, Sticht H, Al-Sanna'A N, Rolfs A, Kulik A, Schulte U, Colleaux L, Abou Jamra R, Fakler B
Zeitschrift: Nature Communications
Jahr der Veröffentlichung: 2017
Band: 8
Seitenbereich: 15910
ISSN: 2041-1723


AMPA-type glutamate receptors (AMPARs), key elements in excitatory neurotransmission in the brain, are macromolecular complexes whose properties and cellular functions are determined by the co-assembled constituents of their proteome. Here we identify AMPAR complexes that transiently form in the endoplasmic reticulum (ER) and lack the core-subunits typical for AMPARs in the plasma membrane. Central components of these ER AMPARs are the proteome constituents FRRS1l (C9orf4) and CPT1c that specifically and cooperatively bind to the pore-forming GluA1-4 proteins of AMPARs. Bi-allelic mutations in the human FRRS1L gene are shown to cause severe intellectual disability with cognitive impairment, speech delay and epileptic activity. Virus-directed deletion or overexpression of FRRS1l strongly impact synaptic transmission in adult rat brain by decreasing or increasing the number of AMPARs in synapses and extra-synaptic sites. Our results provide insight into the early biogenesis of AMPARs and demonstrate its pronounced impact on synaptic transmission and brain function.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Buchert, Rebecca
Lehrstuhl für Humangenetik
Sticht, Heinrich Prof. Dr.
Professur für Bioinformatik

Einrichtungen weiterer Autorinnen und Autoren

Albert-Ludwigs-Universität Freiburg
ARAMCO - Dharan Health Center
Hopital Benaknoun
University of Paris 5 - René Descartes / Université Paris V René Descartes


Brechet, A., Buchert, R., Schwenk, J., Boudkkazi, S., Zolles, G., Siquier-Pernet, K.,... Fakler, B. (2017). AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability. Nature Communications, 8, 15910.

Brechet, Aline, et al. "AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability." Nature Communications 8 (2017): 15910.


Zuletzt aktualisiert 2018-10-10 um 08:21