Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites

Journal article


Publication Details

Author(s): Vargas GE, Haro Durand LA, Cadena V, Romero M, Vera Mesones R, Mackovic M, Spallek S, Spiecker E, Boccaccini AR, Gorustovich AA
Journal: Journal of Materials Science-Materials in Medicine
Publisher: Springer Verlag (Germany)
Publication year: 2013
Volume: 24
Journal issue: 5
Pages range: 1261-1269
ISSN: 0957-4530


Abstract


Angiogenesis is essential for tissue regeneration and repair. A growing body of evidence shows that the use of bioactive glasses (BG) in biomaterial-based tissue engineering (TE) strategies may improve angiogenesis and induce increased vascularization in TE constructs. This work investigated the effect of adding nano-sized BG particles (n-BG) on the angiogenic properties of bovine type I collagen/n-BG composites. Nano-sized (20-30 nm) BG particles of nominally 45S5 Bioglass composition were used to prepare composite films, which were characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The in vivo angiogenic response was evaluated using the quail chorioallantoic membrane (CAM) as an model of angiogenesis. At 24 h post-implantation, 10 wt% n-BG containing collagen films stimulated angiogenesis by increasing by 41 % the number of blood vessels branch points. In contrast, composite films containing 20 wt% n-BG were found to inhibit angiogenesis. This experimental study provides the first evidence that addition of a limited concentration of n-BG (10 wt%) to collagen films induces an early angiogenic response making selected collagen/n-BG composites attractive matrices for tissue engineering and regenerative medicine. © Springer Science+Business Media New York 2013.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Spallek, Stefanie
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Mackovic, Mirza Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Spiecker, Erdmann Prof. Dr.
Lehrstuhl für Werkstoffwissenschaften (Mikro- und Nanostrukturforschung)


Additional Organisation
Interdisziplinäres Zentrum, Center for Nanoanalysis and Electron Microscopy (CENEM)


External institutions with authors

Instituto de Tecnologías y Ciencias de la Ingeniería "Hilario Fernández Long" (INTECIN)
Universidad Nacional de Salta


How to cite

APA:
Vargas, G.E., Haro Durand, L.A., Cadena, V., Romero, M., Vera Mesones, R., Mackovic, M.,... Gorustovich, A.A. (2013). Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites. Journal of Materials Science-Materials in Medicine, 24(5), 1261-1269. https://dx.doi.org/10.1007/s10856-013-4892-7

MLA:
Vargas, Gabriela E., et al. "Effect of nano-sized bioactive glass particles on the angiogenic properties of collagen based composites." Journal of Materials Science-Materials in Medicine 24.5 (2013): 1261-1269.

BibTeX: 

Last updated on 2019-29-05 at 16:05