A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants

Journal article
(Original article)


Publication Details

Author(s): Macon ALB, Kim TB, Valliant EM, Goetschius K, Brow RK, Day DE, Hoppe A, Boccaccini AR, Kim IY, Ohtsuki C, Kokubo T, Osaka A, Vallet-Regi M, Arcos D, Fraile L, Salinas AJ, Teixeira AV, Vueva Y, Almeida RM, Miola M, Vitale-Brovarone C, Verne E, Höland W, Jones JR
Journal: Journal of Materials Science-Materials in Medicine
Publisher: Springer Verlag (Germany)
Publication year: 2015
Volume: 26
ISSN: 0957-4530


Abstract


The aim of this study was to propose and validate a new unified method for testing dissolution rates of bioactive glasses and their variants, and the formation of calcium phosphate layer formation on their surface, which is an indicator of bioactivity. At present, comparison in the literature is difficult as many groups use different testing protocols. An ISO standard covers the use of simulated body fluid on standard shape materials but it does not take into account that bioactive glasses can have very different specific surface areas, as for glass powders. Validation of the proposed modified test was through round robin testing and comparison to the ISO standard where appropriate. The proposed test uses fixed mass per solution volume ratio and agitated solution. The round robin study showed differences in hydroxyapatite nucleation on glasses of different composition and between glasses of the same composition but different particle size. The results were reproducible between research facilities. Researchers should use this method when testing new glasses, or their variants, to enable comparison between the literature in the future.



FAU Authors / FAU Editors

Boccaccini, Aldo R. Prof. Dr.-Ing.
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)
Hoppe, Alexander
Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)


External institutions with authors

Chubu University / 中部大学 Chūbu Daigaku
Imperial College London / The Imperial College of Science, Technology and Medicine
Missouri University of Science and Technology
Nagoya University / 名古屋大学
Okayama University / 岡山大学 Okayama daigaku
Politecnico di Torino
Universidad Complutense de Madrid (UCM)
Universidade Nova de Lisboa


How to cite

APA:
Macon, A.L.B., Kim, T.B., Valliant, E.M., Goetschius, K., Brow, R.K., Day, D.E.,... Jones, J.R. (2015). A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. Journal of Materials Science-Materials in Medicine, 26. https://dx.doi.org/10.1007/s10856-015-5403-9

MLA:
Macon, Anthony L. B., et al. "A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants." Journal of Materials Science-Materials in Medicine 26 (2015).

BibTeX: 

Last updated on 2019-22-08 at 21:50