Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging

Journal article

Publication Details

Author(s): Shiroishi MS, Castellazzi G, Boxerman JL, D'Amore F, Essig M, Nguyen TB, Provenzale JM, Enterline DS, Anzalone N, Dörfler A, Rovira A, Wintermark M, Law M
Journal: Journal of Magnetic Resonance Imaging
Publication year: 2015
Volume: 41
Journal issue: 2
Pages range: 296-313
ISSN: 1053-1807


Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is used to track the first pass of an exogenous, paramagnetic, nondiffusible contrast agent through brain tissue, and has emerged as a powerful tool in the characterization of brain tumor hemodynamics. DSC-MRI parameters can be helpful in many aspects, including tumor grading, prediction of treatment response, likelihood of malignant transformation, discrimination between tumor recurrence and radiation necrosis, and differentiation between true early progression and pseudoprogression. This review aims to provide a conceptual overview of the underlying principles of DSC-MRI of the brain for clinical neuroradiologists, scientists, or students wishing to improve their understanding of the technical aspects, pitfalls, and controversies of DSC perfusion MRI of the brain. Future consensus on image acquisition parameters and postprocessing of DSC-MRI will most likely allow this technique to be evaluated and used in high-quality multicenter studies and ultimately help guide clinical care.

FAU Authors / FAU Editors

Dörfler, Arnd Prof. Dr.
Neuroradiologische Abteilung im Radiologischen Institut

External institutions
Brown University
Duke University
Ospedale San Raffaele (früher: Centro San Raffaele del Monte Tabor Foundation)
Università degli Studi di Pavia
University of Manitoba
University of Ottawa
University of Southern California (USC)
University of Virginia (UVA)
Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron

How to cite

Shiroishi, M.S., Castellazzi, G., Boxerman, J.L., D'Amore, F., Essig, M., Nguyen, T.B.,... Law, M. (2015). Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging. Journal of Magnetic Resonance Imaging, 41(2), 296-313.

Shiroishi, Mark S., et al. "Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging." Journal of Magnetic Resonance Imaging 41.2 (2015): 296-313.


Last updated on 2018-10-10 at 08:19