Prognostic significance of altered miRNA expression in whole blood of OSCC patients

Ries J, Baran C, Wehrhan F, Weber M, Neukam FW, Krautheim-Zenk A, Nkenke E (2017)


Publication Type: Journal article

Publication year: 2017

Journal

Book Volume: 37

Pages Range: 3467-3474

Journal Issue: 6

DOI: 10.3892/or.2017.5639

Abstract

Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21). Fold-changes and significance of the differences in miRNA expression levels between the groups were determined. A cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined. Significant differences in the miRNA expression in whole blood of the R-OC and NR-OC groups were found. The levels of miR-3651 and miR-494 were significantly increased and the level of miR-186 was significantly decreased in whole blood of the R-OC patients (pmiR-3651=0.001, pmiR-494=0.003 and pmiR-186=0.001). By the determination of the COP, increased or decreased expression of the markers was significantly correlated to the recurrence of the disease. Altered expression of miR-494, miR-3651 and miR-186 appears to be associated with the recurrence of OSCC. The present study may form the basis for establishing a blood test as a minimally invasive method for the detection of the recurrence of OSCC.

Authors with CRIS profile

Involved external institutions

How to cite

APA:

Ries, J., Baran, C., Wehrhan, F., Weber, M., Neukam, F.W., Krautheim-Zenk, A., & Nkenke, E. (2017). Prognostic significance of altered miRNA expression in whole blood of OSCC patients. Oncology Reports, 37(6), 3467-3474. https://dx.doi.org/10.3892/or.2017.5639

MLA:

Ries, Jutta, et al. "Prognostic significance of altered miRNA expression in whole blood of OSCC patients." Oncology Reports 37.6 (2017): 3467-3474.

BibTeX: Download